摘要
目的 探讨镁离子（Ｍｇ２＋ ）对脑缺血再灌注损伤的保护作用。方法 用线栓法建立脑缺血再灌注模型，观察Ｍｇ２＋ 对脑缺血再灌注损伤的保护作用及对肿瘤坏死因子（ＴＮＦ）和细胞粘附分子（ＩＣＡＭ）表达的影响。结果 Ｍｇ２＋ 治疗组和脑缺血再灌注组ＴＮＦ和ＩＣＡＭ 表达较对照组明显增加，神经功能缺陷评分下降，但Ｍｇ２＋ 治疗组和脑缺血再灌注组之间ＴＮＦ和ＩＣＡＭ 表达无显著差异。结论 Ｍｇ２＋ 对脑缺血再灌注损伤具有保护作用，但不影响ＴＮＦ和ＩＣＡＭ 的表达。
Objective To explore the protective effect of magnesium ion(Mg 2+ ) on cerebral ischemic reperfusive injury.Methods Using thread embolism method to develop the model of cerebral ischemic reperfusion in rat, we observed Mg 2+ protective effect on cerebral ischemic reperfusive injury and the influence on the expression of tumor necrosis factor(TNF) and intracellular adhesion molecular(ICAM).Results The expressions of TNF and ICAM in Mg 2+ therapeutic group and the cerebral ischemic reperfusive group were higher significantly than those of the control, the neurological functional deficit scales were low, but there was no significant difference between Mg 2+ therapeutic group and the cerebral ischemic reperfusive group.Conclusion Mg 2+ had protective effect on cerebral ischemic reperfusive injury, but it did not influence the expression of TNF and ICAM.
出处
《临床神经病学杂志》
CAS
1999年第5期261-262,共2页
Journal of Clinical Neurology
关键词
镁离子
脑缺血
再灌注损伤
药理
Magnesium ion Cerebral ischemia Reperfusion injury
