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阿托伐他汀对高血压肾病蛋白尿和肾功能不全的疗效观察 被引量:8

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摘要 目的研究阿托伐他汀对血压控制正常的高血压肾病患者尿蛋白,肾功能的影响。方法 56例血压控制正常的高血肾病患者随机分为观察组和对照组,观察组予以阿托伐他汀10mg/d,对照组予以安慰剂,观察6个月后,两组血脂(TG、TC)、肾功能(肌酐(Cr),尿酸(Ua)尿素氮(BUN))、24h尿蛋白(U-Pro)变化。结果治疗6月后,观察组的TC、TG、U-Pro,BUN较对照组均显著降低(P〈0.05)。结论阿托伐他汀对高血压肾病患者蛋白尿及轻度慢性肾功能不全具有一定治疗作用。
作者 付慧 陈小军
出处 《医学信息》 2011年第7期2025-2025,共1页 Journal of Medical Information
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参考文献6

  • 1Virdis A, Schiffrin, Ernesto I., Vascular intlamnaation: a role in vascular disease in hypertension[J].Current opinion in neph- rology and hypertension, 2003,12:181 - 187.
  • 2吴旭斌,杨成悌,余静,张缤.炎症在高血压病患者肾功能损害中的作用[J].高血压杂志,2003,11(1):16-18. 被引量:45
  • 3成威,周胜华,张铭,李旭平.阿托伐他汀对高血压肾病蛋白尿及C-反应蛋白和白介素-6的影响[J].高血压杂志,2005,13(12):767-770. 被引量:43
  • 4Shepherd J, Kastelein JJ, Bittner VA, et al.lntensive lipid lowering with atorvas- tatin in patients with coronary heart disease and chronic kidney disease [J].Am J Cardiol,2008 ; 51(15) : 1448-54.
  • 5Epstein M,Campese VM Pleiotropic effects of 3 hydroxy 3 Methylglutaryl coenzyme a reductase inhibitors on renal function[J].Am J KidneyDis,2005,45 : 2- 14.
  • 6Yokta N,ODonnell M,Daniels F,et al.Protective effect of HMG-CoAreductase inhibitor on experimental ~enal ischemia reperfusion injary [J].Am J Nephrol, 2003,23(1) : 13-7.

二级参考文献12

  • 1Virdis A,Schiffrin,Ernesto L.Vascular inflammation:a role in vascular disease in hypertension[J].Current opinion in nephrology and hypertension,2003,12:181-187.
  • 2Shlipak MG,Fried LF,Crump C,et al.Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency[J].Circulation,2003,107:87-92.
  • 3Epstein M,Campese VM.Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on renal function[J].Am J Kidney Dis,2005,45:2-14.
  • 4Arici M,Walls J.End-stage renal disease,atherosclerosis,and cardiovascular mortality:is C-reactive protein the missing link[J].Kidney Int,2001,59:407-414.
  • 5Soy RC,Kastelein J J,Arisz L,et al.Atorvastatin and the dyslipidemia of early renal failure[J].Atherosclerosis,2003,166:187-194.
  • 6Shah S,Paparello J,Danesh FR.Effects of statin therapy on the progression of chronic kidney disease[J].Adv Chronic Kidney Dis,2005,12:187-195.
  • 7Bianchi S,Bigazzi R,Caiazza A,et al.A controlled prospective study of the effects of atorvastatin on proteinuria and progression of kidney disease[J].Am J Kidney Dis,2003,41:565-570.
  • 8Lee TM,Su SF,Tsai CH.Effect of pravastatin on proteinuria in patients with well-controlled hypertension[J].Hypertension,2002,40:67-73.
  • 9Park JK,Muller DN,Mervaala EM,et al.Cerivastatin prevents angiotensin Ⅱ induced renal injury independent of blood pressure and cholesterol-lowering effects[J].Kidney Int,2000,58:1420-1430.
  • 10Ehdad A,Ali AH,Katie V,et al.Beneficial effects of statins on the kidney:the evidence moves from mouse to man[J].Nephrol Dial Transplant,2004,19:1032-1036.

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