摘要
目的 探讨大细胞肺癌（LCLC）的临床病理特征及预后影响因素.方法 回顾性分析111例LCLC患者的临床资料,采用单因素和多因素分析方法分析预后的影响因素.结果 111例LCLC中,病灶位于右肺53例,其中位于上叶26例 病灶位于左肺58例,其中位于上叶35例.中央型36例,周围型75例.肿瘤平均直径为5.3 cm.Ⅰ期38例,Ⅱ期11例,Ⅲ期45例,Ⅳ期17例.淋巴结转移60例,远处转移17例.111例LCLC患者1、3、5年生存率分别为54.7%、30.9%和20.6%.单因素分析显示,N分期、M分期和TNM分期与患者预后有关（均P=0.000）.多因素分析显示,TNM分期是患者预后的独立影响因素（P=0.000）.结论 LCLC预后较其他非小细胞肺癌差,根治性手术是主要治疗手段,影响其预后的独立因素是TNM分期.
Objective The aim of this study was to explore the clinical characteristics and analyze the prognostic factors of large cell lung cancer（LCLC）. Methods The clinical data of 111 LCLC cases were collected and retrospectively analyzed. The prognostic factors were evaluated by univariate and multivariate analyses. Results Among the 111 cases, the lesions were in the right lung of 53 patients and 26 of them were located in the superior lobe. The lesions were in the left lung of 58 cases, and 35 of them were in the superior lobe. The lesions were presented as central in 36 cases and peripheral in 75 cases, with a mean diameter of 5.3 cm. All the 111 patients were diagnosed as stage Ⅰ in 38 cases, stage Ⅱ in 11cases, stage Ⅲ in 45 and stage Ⅳ in 17 cases. 60 patients had lymph node metastasis and 17 cases had distant metastasis. The overall 1-, 3- and 5- year survival rates of the LCLC were 54.7%, 30. 9% and 20.6%, respectively. Cox univariate analysis revealed that TNM stage（P =0.000）, lymph node metastasis （P =0.000）and M stage（P =0.000）are prognostic factors. Cox multivariate analysis indicated that TNM stage（P = 0.000）is an independent prognostic factor. Conclusion The prognosis of LCLC is worse than other types of non-small cell lung cancer. Complete surgical resection remains the main therapeutic approach. TNM stage is an independent prognostic factor.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2010年第12期932-934,共3页
Chinese Journal of Oncology
关键词
大细胞肺癌
临床特征
预后
Large cell lung cancer Clinical characteristics Prognosis
作者简介
通信作者：李凯，Email：likai5@medmail．com．cn
