摘要
机械刺激在骨组织的正常代谢和重建过程中起着十分重要的作用。机械刺激作用于骨组织后可以通过包括成骨细胞在内的多种应力感受细胞,感知并传导力学信号。细胞骨架作为贯穿细胞整体的纤维网状支架结构,与细胞外基质及整合素构成一个整体,是力学信号传递的关键环节之一。力学刺激可引起骨架纤维重排并可借助第二信使将力学信号传递并转换,最终调节基因的表达。该信号通路涉及的分子主要包括Rho家族、蛋白激酶C以及黏附斑激酶。本文将就近几年关于机械刺激下成骨细胞骨架的改变及作用机制的研究进展进行综述。
Mechanical stimulation plays an important role in the normal metabolism and reorganization of bone.Many kinds of stress-sensitive cells,including osteoblasts,can perceive and transduce the mechanical signals.As the fibrous framework throughout a cell,cytoskeleton as well as extracellular matrix and integrin is one of the critical components in mechanotransduction.Mechanical stimulation can induce the rearrangement of the cy-toskeleton,and the signals are transduced and transformed by the second messagers,finally resulting in the changes of gene expression.The family of Rho,protein kinase C and focal adhesion kinase are the main messa-ges involved in this process.This paper summarizes the recent advances about the effects and possible mecha-nism of mechanical stimulation on osteoblast cytoskeleton.
出处
《医用生物力学》
EI
CAS
CSCD
2011年第1期87-91,共5页
Journal of Medical Biomechanics
关键词
机械刺激
成骨细胞
细胞骨架
信号转导
Mechanical stimulation
Osteoblasts
Cytoskeleton
Signal transduction
作者简介
通讯作者：房兵，Tel：（021）23271699-5339；E-mail：bmces_dr@hotmail．com。
