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4-芳氨基-67,-二甲氧基喹唑啉的合成及生物活性研究

Synthesis and bioactivity of 4-arylamino-6,7-dimethoxyl quinazoline derivatives
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摘要 以4-氯-67,-二甲氧基喹唑啉和4-(2-芳基)乙烯基苯胺或4-[2-(2-呋喃基)]乙烯基苯胺为原料合成了5种4-芳氨基-6,7-二甲氧基喹唑啉类化合物。利用IR、NMR和元素分析等表征手段对其进行了结构确认。这5种化合物对HT-29和MDA-MB-231两种细胞模型的体外抗癌活性测试结果表明,部分化合物具有良好的抗肿瘤活性。 Five 4-arylamino-6,7-dimethoxyl quinazoline derivatives were synthesized from 4-chloro-6,7-dimethoxyl quinazoline and 4-（2-arylethenyl）aniline or 4-[2-（2-furyl）ethenyl]aniline.The structures of the five compounds were characterized by elemental analysis,IR and NMR spectra.Bioactivities of the new compounds were tested.The results showed that some of them possessed benign anti-cancer activity to HT-29,MDA-MB-231 cells.
作者 王孝妹 刘小莉 张喜全 顾红梅 徐宏江 王留昌 李宝林
机构地区 教育部药用资源与天然药物化学重点实验室 江苏正大天晴药业股份有限公司
出处 《化学研究与应用》 CAS CSCD 北大核心 2011年第3期317-321,共5页 Chemical Research and Application
基金 国家自然科学基金资助项目(20972090) 陕西师范大学理工科中央高校基本科研业务费专项资助项目(GK200901010)
关键词 喹唑啉类化合物 抗肿瘤活性 合成 quinazoline derivatives anti-tumor activity synthesis
分类号 O626 [理学—有机化学]
作者简介 李宝林（1959-），男，教授，主要研究方向：药物合成及天然药物化学研究。Email：baolinli@snnu．edu．cn
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参考文献13

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化学研究与应用
2011年 第3期

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