期刊文献+

血清S100A8/A9、MMP-2水平变化与急性冠状动脉综合征的关系 被引量:6

在线阅读 下载PDF
导出
摘要 目的:观察急性冠脉综合征(ACS)患者外周静脉血清S100A8/A9、基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)水平并评价其临床意义。方法:选取ACS患者84例为ACS组,其中急性心肌梗死(acute myocardial infarction,AMI)43例,不稳定型心绞痛(unstable angina,UA)41例。正常对照组为健康体检患者,选用23例作为对照。用酶联免疫吸附法(enzyme-linked immunosorbnent assay,ELISA)检测血清S100A8/A9、MMP-2水平。结果:AMI组、UA组血清S100A8/A9、MMP-2水平高于对照组(P<0.01);AMI组和UA组血清S100A8/A9、MMP-2的水平有显著差异(P<0.01)。ACS组患者血清S100A8/A9与MMP-2水平无相关性(R=0.151,P>0.05)。结论:S100A8/A9、MMP-2在ACS患者的高表达提示可能与动脉粥样斑块的形成有关,联合检测血清S100A8/A9、MMP-2可能成为一种有效的预测急性心血管事件发生的临床指标。
机构地区 苏州大学附三院
出处 《实用医学杂志》 CAS 北大核心 2010年第24期4528-4530,共3页 The Journal of Practical Medicine
作者简介 通信作者:孙建辉E-mailsunjianh@yahoo.com.cn
  • 相关文献

参考文献7

二级参考文献29

共引文献28

同被引文献38

  • 1汪祥海,伍卫,杨军,方昶,耿登峰,黄至斌.Rho激酶在血管紧张素Ⅱ刺激大鼠心肌成纤维细胞增殖和胶原合成中的作用[J].中国病理生理杂志,2007,23(6):1098-1101. 被引量:16
  • 2Chorianopoulos E,Jarr K,Steen H. Soluble TWEAK is markedly upregulated in patients with ST-elevation myocardial infarction and related to an adverse short-term outcome[J].Atheroclerosis,2010,(01):322-326.
  • 3Moreno J A,Munoz-Garcia B,Martin-Ventra J L. The CD163-expressing macrophages recognize and internalize TWEAK:potential consequences in atherosclerosis[J].Atheroclerosis,2009,(01):103-110.
  • 4Munoz-Garcia,Martin-Ventara J L,Mavtinez E. Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques:modulation by atorvastatin[J].Stroke,2006,(08):2044-2053.doi:10.1161/01.STR.0000230648.00027.00.
  • 5Yamana J,Morand E F,Manabu T. Inhibition of TNF-induced IL-6 by the TWEAK-Fn14 interaction in rheumatoid arthritis fibroblast like synoviocytes[J].Cellular Immunology,2012,(02):293-298.
  • 6Roos C,Wicovsky A,Mullev N. Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway[J].Journal of Immunology,2010,(03):1593-1605.
  • 7El-Shehaby A,Danweesh H,EI-khatib M. Correlations of urinary biomarkers,TNF-like weak inducer of apoptosis (TWEAK),osteoprotegerin (OPG),monocyte chemoattractant protein-1 (MCP-1),and IL-8 with lupus nephritis[J].Journal of Clinical Immunology,2011,(05):848-856.
  • 8Aileen M. Healy,Michael D. Pickard,Aruna D. Pradhan,Yunmei Wang,Zhiping Chen,Kevin Croce,Masashi Sakuma,Can Shi,Alexandre C. Zago,Joseph Garasic,Andrew I. Damokosh,Tracy L. Dowie,Louis Poisson,James Lillie,Peter Libby,Paul M. Ridker,Daniel I. Simon.Platelet Expression Profiling and Clinical Validation of Myeloid-Related Protein-14 as a Novel Determinant of Cardiovascular Events[J].Circulation.2006(19)
  • 9徐全波,樊永平,刘永欣,于悦卿.急性心肌梗死后左心室重构的研究进展[J].中国医药,2008,3(2):124-126. 被引量:4
  • 10佟浩,张曼.RhoA经基质金属蛋白酶-3、-9通路介导心力衰竭大鼠心肌重塑及心功能恶化[J].解剖学杂志,2008,31(2):173-176. 被引量:7

引证文献6

二级引证文献35

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部