期刊文献+

Apelin与高血压、糖尿病与肥胖的研究进展 被引量:2

在线阅读 下载PDF
导出
摘要 Apelin是1998年由Tatemoto等[1]首次通过反向药理学方法从牛胃的分泌物中提取并纯化的孤儿G蛋白耦联受体——血管紧张素受体相关蛋白(angiotensin receptor—likeprotein J,APJ)的天然配体,是一种新发现的具有重要生物学作用的心血管活性多肽,属于肾素一血管紧张素一醛固酮系统(RAS)新的组分。
出处 《临床荟萃》 CAS 2011年第5期444-446,共3页 Clinical Focus
  • 相关文献

参考文献18

  • 1Tatemoto K, Hosova M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor[J]. Biochem Biophys Res Commun, 1998,251(2):471-476.
  • 2O'Carroll AM, Selby TL, Palkovits M, et al. Distribution of mRNAencoding B78/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain andperipheral tissues[J]. Bioehim Biophys Acta, 2000, 1492 (1) : 72-80.
  • 3Boucher J, Masri B, Daviaud D, et al. Apelin, a newly identified adipkine up-regulated by insulin and obesity [J]. Endocrinology,2005,1 (4) : 1764-1771.
  • 4Wei L, Hou X, Tatemoto K. Regulation of apelin mRNA expression by insulin and glucocorticoids in mouse 3T3-L1 aclipoeytes[J]. Regul Pept, 2005, 132( 1/3 ) : 27-32.
  • 5Heinonen MV, Purhonen AK, Miettinen P, et al. Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding[J]. Regul Pept,2005,130(1/2) 7-13.
  • 6Castan-Laurell I, Vitkova M, Daviaud D, et al. Effect of hypocalorie diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ[J]. Eur J Endoerinol,2008,158(6) :905-910.
  • 7Tatemoto K, Takayama K, Zou MX, et ah The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism[J]. Regul Pept,2001,99(2 /3) : 87-92.
  • 8Jia YX,Lu ZF,Zhang J ,et al. Apelin activates L-arginine/nitric oxide synthase/nitricoxide pathway in rat aortas[J].. Peptides, 2007,28(10) ,2023-2029.
  • 9Ishida J, Hashimoto T, Hashimoto Y, et M. Regulatotyroles for APJ,aseven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo[J]. Biol Chem, 2004, 279(25) :26274-26279.
  • 10Gurzu B, Petrescu BC, Costuleanu M, et al. Interactions between apelin and angiotensin Ⅱ on rat portal vein [J]. J RAAS, 2006,7(4) : 212-16.

同被引文献7

引证文献2

二级引证文献19

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部