摘要
目的探讨原发性胃淋巴瘤(PGL)的临床病理和内镜下表现,提高对PGL的认识。方法对我院1999年1月～2010年3月经内镜检查、组织病理和免疫组化确诊的42例PGL的临床资料并进行分析。结果42例患者从发病到就诊时间平均5.2个月。首发症状为上腹部疼痛,依次有腹部饱胀、食欲减退、呕血与黑便、贫血、消瘦等临床表现。内镜下形态表现分弥散浸润型(17例)、多发溃疡型(14例)和隆起糜烂型(11例)。多部位、多种形态且病变范围广为其特征。内镜下常误诊为胃癌、溃疡等,需经病理学、免疫组化检查确诊。本组38例(90.5%)幽门螺杆菌(Hp)阳性。结论PGL起病较隐匿、病程较长。症状、体征不具特异性。内镜下多点深取组织活检及病理学、免疫组化检查是提高PGL确诊率和早期诊断率的重要方法。Hp感染与PGL有密切相关性。
Objective To investigate the clinical and endoscopic features of primary gastric lymphoma（PGL）. Methods The clinical, endoscopic and pathological data of 42 patients with PGL admitted to our hospital from January 1999 to March 2010 was analyzed retrospectively. Results An average of 5.2 months was spent in 42 patients with PGL before it was verified. The main symptom was epigastric pain, and the others were abdominal fullness, loss of appetite, hematemesis and melena, anemia, and weight loss. The endoscopic features included infiltrating type in 17 cases, multiple ulcers in 14 cases, swelling and erosion in 11 cases. PGL was commonly misdiagnosed by endoscopy as gastric carcinoma or gastric ulcer. The final diagnosis was confirmed by pathology and immunohistochemistry. Thirty-two patients （76.2%） were infected with Helicobacter pylori. Conclusions The onset of PGL is latent with long course of disease. It is suggested that multiple deep biopsy, special pathological change and immunohistochemistry are helpful to improve the correct diagnosis. This disease is obviously associated with Helicobacter pylori infection.
出处
《现代消化及介入诊疗》
2010年第6期341-343,共3页
Modern Interventional Diagnosis and Treatment in Gastroenterology
