摘要
目的探讨CYP2C19基因型在江苏及其周边地区汉族人群中基因多态性的分布。方法取81名汉族健康人的外周血,应用聚合酶链反应(PCR)-限制性片段长度多态性分析(RFLP)CYP2C19等位基因分型。结果在81名检测标本中,CYP2C19纯合子强代谢型、杂合子强代谢型和弱代谢型的发生率分别为38.3%、45.7%和16.0%。结论江苏及其周边地区汉族人群存在CYP2C19的基因多态性,其弱代谢型的发生率与中国汉族人总体发生率基本一致。
Objective To investigate distribution status of CYP450 2C19 genotype in Han healthy subjects in Jiangsu Province.Methods The CYP2C19 genotype of 81 Han healthy subjects were determined by the polymerase chain reaction-restriction fragment length polymorphism method（PCR-RFLP）.Results The frequency of CYP2C19 homozygous extensive metabolisms（homEMs）,heterozygous extensive metabolisms（hetEMs） and poor metabolisms（PMs） in the 81 Chinese subjects was 38.3%,45.7% and 16.0%,respectively.Conclusion The frequency of CYP2C19 poor metabolisms coincides with its frequency of Chinese population.
出处
《实用临床医药杂志》
CAS
2011年第1期125-128,共4页
Journal of Clinical Medicine in Practice
