不同剂型硝酸甘油预防ERCP术后胰腺炎的作用分析及安全性评价被引量：4

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摘要目的对不同剂型硝酸甘油预防内镜下逆行胰胆管造影术(ERCP)术后胰腺炎的作用进行系统性评估及药物安全性分析。方法以"硝酸甘油和胰腺炎"为主题词,检索2000～2009发表的关于硝酸甘油预防PEP的随机对照研究(RCT),jadad评分评估文献质量,Revman4.2.8软件行数据统计分析。结果①硝酸甘油组的PEP发生相对风险率为对照组的49%(RR=0.49,95%CI:0.35,0.69,P>0.05);②不同剂型亚组中,舌下含服硝酸甘油片组PEP发生相对风险率为对照组40%(RR=0.40,95%CI 0.20,0.79,P>0.05),透皮贴剂组与对照组的PEP发生率无明显差异;③硝酸甘油组的头痛、低血压发生风险率显著高于对照组,分别为3.27和2.43倍,两组死亡率无差异。结论①硝酸甘油对ERCP术后胰腺炎有预防作用。②舌下含服硝酸甘油预防能明显降低PEP发生率。③硝酸甘油的安全性较好。

作者陈小微吴小丽石大伟

机构地区温州医学院附属第一医院消化内科

出处《中国药学杂志》 CAS CSCD 北大核心 2011年第4期307-310,共4页 Chinese Pharmaceutical Journal

基金温州市科技局课题(Y20090405)

关键词硝酸甘油 ERCP术后胰腺炎 META分析

分类号 R969.3 [医药卫生—药理学]

作者简介陈小微，女，硕士，主治医师研究方向：消化内科学 Tel：（0577）88069256 E-mail：chenwei77128@hotmail．com

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