摘要
目的：评价经鼻持续气道正压通气（NCPAP）联合应用大剂量沐舒坦治疗早期新生儿呼吸窘迫综合征的临床疗效及应用价值。方法：将58例新生儿呼吸窘迫综合征患儿随机分为两组：治疗组（NCPAP联合沐舒坦）30例和对照组（NCPAP组）28例,治疗组在给予NCPAP治疗同时,加用沐舒坦30 mg/（kg.d）,6 h 1次,应用3~5 d。比较分析两组病例的临床表现、血气分析、胸片、并发症及吸氧时间、住院时间。结果：治疗组在临床表现、血气分析、胸片恢复方面与对照组比较,差异有统计学意义（P〈0.05）;治疗组吸氧时间和住院时间与对照组比较,差异有统计学意义（P〈0.05）;治疗组发生并发症2例,对照组7例;治疗组1例、对照组6例分别改机械通气,差异均有统计学意义（P〈0.05）。结论：NCPAP联用大剂量沐舒坦治疗早期新生儿呼吸窘迫综合征是一种经济有效的治疗方法,适合基层医院推广和应用。
Objective：To assess the curative effect and application value of nasal continuous positive airway pressure（NCPAP） combined mucosolvan to treat early neonatal respiratory distress syndrome（NRDS）.Methods：58 NRDS neonates were randomly divided into two groups.On the base of NCPAP treatment,the treatment group（30 cases） was added mucosolvan 30mg/（kgod）,once every 6h for 3~5 d.The control group（28 cases） received only NCPAP treatment.The clinical symptoms after treatment,blood gas,chest radiograph,complications,oxygen time and hospitalized duration in the treatment group were compared with those in the control group.Results：The clinical symptoms and signs,chest radiograph,arterial blood gas indicators in the treatment group were improved more significantly than those in the control group with statistical difference（P0.05）.2 cases in the treatment group and 7 cases in the control group had complication.1 cases in the treatment group and 6 cases in the control group were changed to use mechanic ventilation with statistical difference（P0.05）.Conclusion：NCPAP combined with large dose of mucosolvan is an effective and economical therapeutic method to treat NRDS,which is suitable to application in primary hospitals.
出处
《现代医药卫生》
2011年第1期27-29,共3页
Journal of Modern Medicine & Health
