摘要
目的 研究活性氧(ROS)的表达与肾血管性高血压(RVH)大鼠左室肥厚的关系,探讨ROS在RVH大鼠左室肥厚发生、发展中的作用。方法将20只体重200g左右的雄性W istar大鼠,随机分为2组(n=10),建立两肾一夹肾血管性高血压大鼠左心室肥厚模型:对照组(SHAM)、实验组(2K1C),术后12周终止实验。结果实验组收缩压(SBP)、左心室重量指数(LVM I)、心脏重量指数、心肌胶原容积分数(CVF)及活性氧(ROS)水平均显著高于对照组(P<0.01),而抗氧化酶(SOD和GSH-PX)的活性低于对照组(P<0.01)。结论肾血管性高血压大鼠ROS表达增多,提示ROS参与了肾血管性高血压左心室肥厚的形成过程。
Objective To study the relation between ROS and left ventricular hypertrophy in the rats with renovascular hypertension.Methods Twenty male wistar rats,weighing about 200g each,were randomly divided into two groups（n=10）：negative control group（SHAM）,operation group（2K1C）,at the 12th week to stop experiment.Systolic blood pressure（SBP）was measured,collagen volume fraction（CVF）was detected by Van Gieson,and SOD、GSH-PX、ROS were detected by ELISA.Results The results showed that the SBP、LVMI、CVF and ROS in 2K1C group significantly increased（P0.01）.compared with the SHAM group,but the activities of GSH-Px and SOD were decreased（P0.01）.Conclusion Increased expression of ROS in left ventricular myocardium of rets with renovascular hypertension indicate that ROS may play important roles in the development of ventricular hypertrophy of RVH rats.
出处
《中国实用医药》
2011年第1期26-28,共3页
China Practical Medicine
关键词
高血压
肾血管性
左室肥厚
活性氧
Hypertension
Renovascular
Left ventricular hypertrophy
Reactive Oxygen Species
作者简介
通信作者：魏万林Emal：wei_wanlin@126.com
