摘要
目的:探讨慢性牙周炎患者与其口腔中的幽门螺杆菌(helicobacter pylori,HP)的相关性。方法:依据HP特异的尿素酶C和cagA基因设计引物,建立PCR方法。检测37例牙周炎患者口腔菌斑和含漱液中的HP,同时设立牙周健康对照组,比较两组的检测结果。结果:尿素酶C基因在牙周炎组的阳性率为64.8%,健康组为38.5%;尿素酶C基因和cagA基因共同阳性率在牙周炎组为32.4%,健康组为7.7%;两组差异有统计学意义;且轻型牙周炎患者口腔HP阳性率低于中、重型患者。龈下菌班HP阳性率高于龈上菌斑。结论:HP参与了慢性牙周炎的致病过程,抑或是加强了其它因素的致病过程,HP与牙周炎有相关性。
Objective：To investigate the relationship between Helicobacter pylori（Hp） and periodontitis.Method：A polymerase chain reaction（PCR） assay with oligonucleotide primers homologous to a portion of the u-rease C and cytotoxin-associated gene A（cagA） ofHpwas used to test for the presence ofHpin dental plaque.Thirty-seven patients with periodontitis and 38 healthy persons were studied to compare the results of the two Groups.Result：In the periodontitis group,64.8 % f the tested samples was ureasc gene positive,and 32.4 % was positive for both urease C and cagA genes.In healthy persons,38.5 % of the tested samples was urease C gene posi-tive and 7.7 % was positive for both urease C and cagA genes.There was a significantly difference between the twogroups（P 0.01）.The Hp-positive rate of the major periodontitis was enhanced obviously to minor peciodontitis.The Hp-positive rate of subgingival plaque was significantly higher than that of supragingival plague.Conclusion：HP participates the formation of the chronic periodontitis or it increases the pathogenic effect of other factors.
出处
《临床口腔医学杂志》
2011年第1期5-7,共3页
Journal of Clinical Stomatology
基金
泰安市科技局资助项目(泰科计字[2002]9号)
关键词
幽门螺杆菌
聚合酶链反应
牙周炎
helicobacter pylori
periodontitis
polymerase chain reaction
作者简介
高静：现在山东省泰安市中心医院口腔科工作
通讯作者：朱声荣E-mail：zhushengrong@163．com
