摘要
目的探讨西酞普兰对慢性心力衰竭(CHF)合并抑郁伴或不伴焦虑患者的有效性和安全性。方法选择CHF合并抑郁伴或不伴焦虑的患者1 20例,随机分为治疗组60例和对照组60例。采用汉密尔顿抑郁量表、汉密尔顿焦虑量表、世界卫生组织生活质量评定量表评估治疗前后抑郁、焦虑及生活质量变化;评估心功能分级(NYHA)和6 min步行距离试验(6MWT)、监测血浆氨基末端脑钠肽前体(NT-proBNP)、左心室舒张末内径(LVEDD)及LVEF;采用副反应量表及心电图评估西酞普兰的安全性。结果与治疗前比较,治疗组和时熙组治疗后第4、6、8周末抑郁和焦虑程度明显减轻,第8周末生活质量明显改善,除外第4周末LVEDD,第8周末NYHA、6MWT和LVEF明显增加,血浆NT-proBNP及LVEDD明显降低(P<0.05,P<0.01);与对照组比较,治疗组治疗后第2、4、6、8周末抑郁和焦虑程度明显改善,第8周末生活质量明显改善,第4、8周末NYHA、6MWT、LVEF明显增加,第8周末NT-proBNP明显下降(P<0.05)。结论西酞普兰能明显改善CHF患者的抑郁和焦虑程度及生活质量,从而更显著改善心功能。
Objective To investigate the efficacy and safety of citalopram in patients with chronic heart failure（CHF） complicated with depression with or without anxiety. Methods 120 patients with CHF complicated with depression with or without anxiety were randomly assigned to treatment group （n = 60） and control group （n = 60）. Hamilton Depression Scale,Hamilton Anxiety Scale and quality of life recommended by WHO were used to evaluate respectively the level of depression and anxiety and the quality of life before and after treatment. The effects of citalopram on cardiac function were evaluated with the heart function scale（NYHA）,the distance of 6-minute walk test（6MWT）, the level of plasma NT-proBNP, LVEDD and LVEF. The safety of citalopram was evaluated with adverse reaction scale and ECG. Results Compared with the baseline, pa- tients~ scores of depression and anxiety were decreased significantly after 4-week treatment and the quality of life showed an obvious improvement after 8-week treatment in two groups, and NYHA,6MWT and LVEF were increased obviously, plasma NT-proBNP and LVEDD were de- creased markedly at end of 8-week treatment （P 〈0.05,P〈 0. 01）. Compared with control group, scores of depression and anxiety were decreased distinctly, the quality of life was improved significantly,NYHA score, 6MWT and LVEF were increased markedly and plasma NT-proBNP was decreased obviously in treatment group （P 〈 0.05）. Conclusion Citalopram could reduce the degree of depression and anxiety and improve patients＇ quality of life in patients with CHF complicated with depression and/or anxiety, and, therefore,contributing to improve heart function.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2011年第1期20-23,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
心力衰竭
西酞普兰
抑郁
焦虑
生活质量
heart failure
citalopram
depression
anxiety
quality of life
