摘要
目的:观察黄连解毒汤对自发性高血压大鼠(spontaneously hypertensive rats,SHR)血栓前状态(prothromboticstate,PTS)的影响。方法:24只12周龄雄性SHR随机分为黄连解毒汤组(15 g·kg-1)、卡托普利组(0.0175 g·kg-1)和模型组3组,8只同龄雄性Wistar-Kyoto(WKY)大鼠为空白对照组,通过BP-6动物无创血压测试仪测定各组治疗前血压,连续ig给药6周,每日1次,第1,2,4,6周的第7天下午定时测量各组血压,6周后由腹主动脉取血,检测血清血栓素A2(TXA2),6-酮前列环素(6-K-PG),一氧化氮(NO),内皮素-1(ET-1),纤溶系统激活剂(t-PA),纤溶系统抑制因子(PAI-1),同型半胱氨酸(Hcy)和血管性血友病因子(vWF)。结果:黄连解毒汤可控制SHR血压,降低TXA2,ET-1,Hcy和vWF(P<0.05或P<0.01),增加6-K-PG和NO(P<0.05或P<0.01)。结论:黄连解毒汤可降低SHR的血压,改善其PTS。
Objective：To observe the effects of Huanglian Jiedu Decoction on prothrombotic state（PTS） in spontaneous hypertension rats（SHR）.Method：Twenty-four SHR were randomly divided into the Huanglian Jiedu Decoction treated group,captopril treated group and model group;eight Wistar-Kyoto Rats were used as the blank group.The groups were treated by Huanglian Jiedu Decoction,captopril and distilled water respectively for six weeks.Blood pressure（BP） were measured at the beginning of the experiment and the end of every week in the experiment,and after six weeks,thromboxane A2（TXA2）,6-Keto-prostaglandin（6-K-PG）,nitric oxide（NO）,endothelin-1（ET-1）,tissue type plasminogen activator（t-PA）,Plasminogen activator inhibitor-1（PAI-1）,homocysteic acid（Hcy） and von Willebrand factor（vWF） of plasma were determined respectively.Result： Huanglian Jiedu Decoction could control the BP of the SHR and decrease the content of TXA2,ET-1,Hcy,vWF（P 0.05 or P 0.01） and increase the content of 6-K-PG,NO（P 0.05 or P 0.01）.Conclusion：Huanglian Jiedu Decoction could control the BP and improve the PTS in the SHR.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第2期105-108,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广西科学基金项目(桂科自0832177)
关键词
黄连解毒汤
自发性高血压大鼠
血压
血栓前状态
Huanglian Jiedu Decoction
spontaneous hypertension rats
blood pressure
prothrombotic state
作者简介
张志伟，硕士，助理实验师，研究方向：生化药理，Tel：13481081452，E-mail：wuqiong00009@163．com
[通讯作者]岳桂华，博士，副主任医师，硕士生导师，研究方向：中西医结合心血管疾病基础与临床研究，Tel：15878551616，E-mail：sdygh1969@163．com
