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TNF-α、MMP-9在扁平苔藓皮损中的表达及意义

The expression and significance of TNF-α and MMP-9 in lichen planus
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摘要 目的:探讨肿瘤坏死因子-α(TNF-α)和基质金属蛋白酶-9(MMP-9)在扁平苔藓发病中的作用。方法:采用免疫组织化学法和RT-PCR方法检测扁平苔藓皮损处及正常组织中TNF-α和MMP-9的表达情况。结果:两者在患者组中的表达高于正常对照组。结论:TNF-α和MMP-9可能参与了扁平苔藓的发病。 Objective:To explore the effect of TNF-α and MMP-9 on the pathogenesis of lichen planus.Methods:Immunchistochemical technique and RT-PCR were used to test the expression of TNF-αand MMP-9 in the cases of lichen planus and normal skin.Results:The expression of TNF-α and MMP-9 in the cases of lichen planus were more than those in the cases of normal skin.Conclusion:TNF-α and MMP-9 may contribute to the progression of lichen planus.
作者 宋育瑶 白莉
出处 《中国当代医药》 2011年第1期5-6,共2页 China Modern Medicine
关键词 扁平苔藓 肿瘤坏死因子-Α 基质金属蛋白酶-9 Lichen planu TNF-α MMP-9
作者简介 宋育瑶(1985-),女,山西医科大学第一区院皮肤科在读研究生,主要从事扁平苔藓的病理研究。 白莉(1958-),女,主任医师,硕士,硕士生导师。中华医学会山西省皮肤性病委员会副主任委员,《美中皮肤性病》杂志编委,山西医科大学第一医院皮肤性病科主任,皮肤性病教研室主任。主要从事皮肤病、性病的临床教学及科研工作。
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