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葛根素对急性冠状动脉综合征患者外周血组织因子和组织因子途径抑制物含量的影响 被引量:6

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摘要 目的观察葛根素对急性冠状动脉综合征(ACS)患者外周血组织因子(TF)、组织因子途径抑制物(TFPI)的影响,从临床角度探讨葛根素在ACS防治中的作用。方法临床入选52例ACS患者随机分为两组:常规治疗组[n=22,男13例,女9例,平均年龄(63.45±5.23)岁]和常规治疗加葛根素组[n=30,男18例,女12例,平均年龄(65.82±8.16)岁],两组患者均治疗10d。采用酶联免疫吸附法测定两组患者治疗前后外周血TF、TFPI水平。结果 (1)常规治疗组和葛根素组患者治疗前外周血TF、TFPI含量分别为(57.91±9.92)pg/ml和(56.22±8.71)pg/ml、(158.32±19.71)ng/ml和(156.86±20.50)ng/ml,组间差异无统计学意义(P>0.05)。(2)治疗后常规治疗组和葛根素组患者外周血TF、TFPI含量分别为(47.19±10.20)pg/ml和(39.81±6.93)pg/ml、(191.85±21.82)ng/ml和(207.92±23.36)ng/ml,与治疗前相比及组间比较差异均有统计学意义(P<0.05)。结论葛根素可以降低ACS患者外周血TF的水平,促进TFPI的表达,可能具有稳定斑块,减少血栓形成的作用。
出处 《中华临床医师杂志(电子版)》 CAS 2010年第11期160-162,共3页 Chinese Journal of Clinicians(Electronic Edition)
基金 江苏省中医药局基金(H05105)
作者简介 通讯作者:李东野,Email:dongyeli@medmail.com.cn
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参考文献14

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