原发性高血压患者血清脂联素和抵抗素水平的变化被引量：5

Changes of adiponectin and resistin levels in patients with essential hypertension

在线阅读下载PDF

导出

摘要目的:探讨脂联素、抵抗素水平与原发性高血压的发生、发展之间的关系。方法:原发性高血压患者114例,根据血压水平分为高血压病1级组(H1)、高血压病2级组(H2)和高血压病3级组(H3),正常血压组(H4,对照组)40例,检测各组组的血清脂联素、抵抗素、血胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白和空腹血糖;计算体质指数。结果:脂联素与收缩压、甘油三酯之间呈直线关系,收缩压、甘油三酯是影响脂联素水平的独立因素;抵抗素与舒张压、高密度脂蛋白、脂联素之间呈直线关系,舒张压、高密度脂蛋白、脂联素是影响抵抗素水平的独立因素。结论:血清脂联素的降低、抵抗素的升高是原发性高血压发生和发展进程中的重要影响因素。 Aim：To investigate the relations between adiponectin,resistin levels and the development of high blood pressure. Methods： One hundred and fifty-four cases are selected from hospital outpatient,in those 40 people with normal blood pressure and 114 patients with essential hypertension.The group of essential hypertension were divided into 3 groups according to the level of blood pressure： a hypertensive 1Grade（H1）,2 Grade hypertension（H2） and 3 Grade hypertension group（H3）.The group of people with normal blood pressure was regarded as compared group（H4）.Serum adiponectin,resistin,blood cholesterol,trigcylglycerol,high-density lipoprotein,low density lipoprotein and fasting plasma glucose were examined in each group.Results： APN and the SBP,TG existed the linear relatwin.SBP,TG is an independent factor affecting the level of APN.RES and DBP,HDL,APN relationship are the linear.DBP,HDL,APN are an independent affecting factors affecting the level of RES.Conclusion：Serum Adiponectin,serum resistin are an important affecting factors of occurrence of development process essential hypertension.

作者黄寰巫少荣李自成陈静平贺佩兰冯嘉贤王中宜张云

机构地区暨南大学附属第一医院心内科广州医学院第三附属医院心内科广州医学院羊城医院内科

出处《暨南大学学报（自然科学与医学版）》 CAS CSCD 北大核心 2010年第4期393-396,共4页 Journal of Jinan University(Natural Science & Medicine Edition)

基金广东省医学科研基金项目(A2009306) 中华医学会心脑血管疾病血糖管理协作组基金项目(08010028) 广东省自然科学基金项目(9151009101000016)

关键词原发性高血压脂联素抵抗素 essential hypertension adiponectin resistin

分类号 R544.1 [医药卫生—心血管疾病]

作者简介黄寰（1966-），男，主治医师．硕士。研究方向：心血管内科疾病诊治研究通讯作者：李自成，教授，博士，Tel：13392691991．E-mail：zichensli@163．net

引文网络
相关文献

参考文献16

1SCHERER P E,WILLIANS S,FOGLIANO M,et al.A novel serumprotein similar to C1q,produced exclusively in adipocytes[J].J Biol Chem,1995,270(45):2646-2649.
2ARITA Y,TOBE T,CHOI-MIURA N H,et al.Paradoxical decrease of anadipose-specific protein in obesity[J].Biochem Biophys Res Commun,1999,257(1):79-83.
3STEPPAN C M,BAILEY S T,BHAT S T,et al.The hormone resistinlinks obesity to diabetes[J].Nature,2001,409(3):307-312.
4OHASHI K,KIHARA S,OUCHI N,et al.Adiponectin replenishment ameliorates obesity-related hypertension[J].Hypertension,2006,47(6):1108-1116.
5CHOW W S,CHEUNG B M,TSO A W,et al.Hypoadiponectinemia as a predictor for the development of hypertension:a 5-year prospective study[J].Hypertension,2007,49(6):1455-1461.
6HAN S H,QUON M J,KIM J A,et al.Adiponectin andcardiovascular disease:response to therapeutic interventions[J].J Am Coll Cardiol,2007,49(5):531-538.
7MAHMUD A,FEELY J.Adiponectin and arterial stiffness[J].Am J Hypertens,2005,18(1):1543-1548.
8RAHMOUNI K,CORREIA M L,HAYNES W G,et al.Obesity-associated hypertension:new insights into mechanisms[J].Hypertension,2005,45(1):9-14.
9XU A,WANG Y,KESHAW H,et al.The fat-derivedhormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice[J].J Clin Invest,2003,112(1):91-100.
10刘美霞,高铁三,康文巧,李如意.老年高血压病患者血清脂联素水平的检测[J].河北医药,2006,28(9):825-826. 被引量：3

二级参考文献67

1李小平,杨成悌,张灵,常鹏.高血压病患者血清脂联素水平的研究[J].中华心血管病杂志,2004,32(7):596-599. 被引量：37
2李新胜.脂联素与2型糖尿病及炎症反应[J].中国全科医学,2005,8(20):1728-1729. 被引量：12
3[1]Steppan CM, Bailey ST, Bchat S et al. The hormone resistin links obesity to diabetes. Nature, 2001, 409:307
4[2]Steppan CM, Yamazawa T, Brown EJ et al. Antagonism of insulin action by resistin. Diabetes, 2001, 50(Suppl 2):A70
5[3]Ferrannini E, Natali A, Capaldo B et al. Insulin resistance, hyperinsulinemia, and blood pressure. Role of age and obesity. Hypertension,1997, 30:1144
6[4]Deurenberg P, Weststrate JA, Seidell JC. Body mass index as a measure of body fatness: age-and sex-specific predition formulas. Br J Nutr,1991, 65:105
7[1]Steppan CM,Bailey ST,Bhat S,et al.The hormone resistin links obesity to diabetes.Nature,20O1,409:307-312.
8[2]Kawanami D,Maemura K,Takeda N,et al.Direct reciprocal effects of resistin and adiponectinon vascular rendothelial cells:A new insight into adipocytokine-endothelial cell interactions.Biochemical and Biophyscial Research Communications,2004,314(2):415-419.
9[3]Paquot N,Tappy L.Adipocytolines:link between obesity,type 2 diabetes and atherosclerosis.Rev Med Liege,2005,6 (5-6):369-373.
10[4]Steppan CM,Yamazawa T,Browne J,et al.Antagonism of insulin action by resistin.Diabetes,2001,50 (Suppl2):70.

共引文献59

1寇忠爱,赵仁亮,王建林,夏秀萍,王晓梅.急性脑梗死患者血浆抵抗素与高血压和血脂及肥胖的相关性[J].中国全科医学,2009,12(2):108-110. 被引量：10
2杨铁勇,李霞.脂联素与心血管疾病的研究[J].兵团医学,2009(3):44-47.
3林兴建,张颖冬.抵抗素与胰岛素抵抗[J].国外医学（脑血管疾病分册）,2004,12(7):548-551.
4林兴建,张颖冬.脑血管病患者血浆抵抗素水平与胰岛素抵抗的相关性研究[J].临床神经病学杂志,2005,18(2):88-90. 被引量：11
5赵杰娉,解金红,李靖.高血压子代人群血清抵抗素的变化[J].中国误诊学杂志,2005,5(4):664-665.
6李靖,赵杰娉,解金红.血清抵抗素在高血压子代人群中的变化[J].临床心血管病杂志,2005,21(7):396-397. 被引量：4
7董平栓,李志娟.抵抗素的研究现状[J].医学综述,2005,11(10):874-875.
8宋玲莉,傅增冸.瘦素、脂联素与高血压的相关性[J].临床内科杂志,2006,23(3):164-166. 被引量：6
9庄玮,成兴波.血浆抵抗素与2型糖尿病及糖尿病微血管病变关系的研究[J].中国血液流变学杂志,2006,16(1):101-103. 被引量：1
10夏章勇,杨华,崔可密,宫殿荣.脑卒中患者急性期血浆抵抗素和瘦素水平及其相关性研究[J].中华老年心脑血管病杂志,2006,8(5):329-332. 被引量：11

同被引文献34

1HU Wen-lan QIAO Shu-bin HOU Qing YUAN Jian-song.Plasma resistin is increased in patients with unstable angina[J].Chinese Medical Journal,2007(10):871-875. 被引量：14
2REILLY M P,LEHRKE M,WOLFE M L,et al.Resistin is aninflammatory marker of atherosclerosis in humans[J].Circulation,2005,22,111(7):932-939.
3MCTERNAN P G,KUSMINSKI C M,KUMAR S.Resistin[J].Curr Opin Lipidol,2006,17(2):170-175.
4FIORUCCI S,RIZZ O G,ANT ONEL LI E,et al.A farnes oid Xreceptor small heterodimer partner regulaory cascade modulates tis-sue metalloproteinase inhibitor-1 and matrix metalloprotease ex-pression in heapistel late cells and promotes resolution of liver fi-brosis[J].J Pharmacol Exp Ther,2005,314(2):584-595.
5KASER S,KASER A,SANDHOFER A,et al.Resistin messen-ger-RNA expression is increased by proinflammatory cytokines invitro[J].Biochem Biophys Res Commun,2003,309(2):286-290.
6Devereux RB, Ajonso DR, Lutas EM, et al. Echocardiographic assessment of left ventricular hypertrophy : Comparison to necropsy findings [ J]. Am J Cardiol,2002,57:450-458.
7] Bell D, McDermott BJ. Intermedin ( adrenomeduUin-2 ) : a novel counter-regulatory peptide in the cardiovascular and renal systems [ J ]. Br J Pharmacol,2008,153 ( Suppl 1 ) : S247-262.
8Mahata SK, Mahata M, Fung MM,et al. Catestatin : a multifunctional peptide chromogranin A[J]. Regul Pept ,2010,162:33-43.
9Liu M, Liu F.Regulation of adiponectin multimerization, signaling and function[J].BestPractResClinEndocrinolMetab, 2014, 28(1): 25-31.
10Ma Y, Liu D.Hydrodynamic delivery of adiponectin and adiponectin receptor 2 gene blocks high-fat diet-inducedobesity and insulin resistance[J].GeneTher, 2013, 20(8): 846-852.