摘要
目的:观察双氯芬酸钠缓释片在治疗紫杉醇所致的肌肉关节疼痛的作用。方法:收集2009年12月～2010年5月川北医学院附属医院肿瘤科使用紫杉醇化疗、发生肌肉关节疼痛的恶性肿瘤患者60例,采用对照研究分为两组:治疗组与对照组。治疗组:口服双氯芬酸钠;对照组:空白对照。按WH0推荐的抗癌药物不良反应分级(0级为无,Ⅰ级为轻度,Ⅱ级中度,Ⅲ级为重度,Ⅳ级为极重)标准评价不良反应。结果:治疗组治疗紫杉醇所致的肌肉关节疼痛,治愈率(0级)为35.0%,有效率(0级+Ⅰ级)为63.3%。结论:口服双氯芬酸钠缓释片减少紫杉醇所致的肌肉关节疼痛发生率,并不同程度地改善疼痛程度。
Objective： To evaluate the effect of diclofenac sodium on prevention of muscle and joint pain induced by paclitaxel. Methods： From Dec. 2009 to May 2010,60 patients received chemotherapy of paclitaxel were randomly divided into two groups： treatment and blank group. The patients in the treatment group received diclofenac sodium to prevent muscle and joint pain induced by paclitaxel, the patients in the blank group did not receive diclofenac sodium. Adverse reaction was evaluated according to WHO evaluation of adverse effect of medicine（0 ranking was none, 1 rank mild, 2 rank moderate, 3 rank severe, 4 rank extremelysevere）. Results： Cure rate of diclofenac sodium for muscle and joint pain induced by paclitaxel was 35.0%, effective rate was 63.3% in treatment group. Conclusion ： Diclofenac sodium can reduce the incidence and relief the degree of muscle and joint pain induced by paclitaxel.
出处
《肿瘤预防与治疗》
2010年第6期467-469,共3页
Journal of Cancer Control And Treatment
关键词
双氯芬酸钠
紫杉醇
肌肉关节疼痛
Diclofenac Sodium
Paclitaxel
Muscle and Joint Pain
作者简介
侯敏（1982-），女，四川平武人，医师，硕士研究生，主要从事肿瘤放化疗，肿瘤综合治疗工作。
[通讯作者]谭榜宪，教授，硕士生导师。
