摘要
目的:探讨中性粒细胞明胶酶相关脂质运载蛋白(NGAL)在2型糖尿病(T2DM)并发肾病患者血清中的表达及临床价值。方法:90例T2DM和30例健康查体者为研究对象,90例T2DM患者根据24 h尿白蛋白水平分为4组:A组,正常蛋白尿组(24 h尿蛋白排泄量(uAlb)<30 mg);B组,微量白蛋白尿组(24 h uAlb 30～300 mg);C组:大量白蛋白尿组(24 h uAlb>300 mg)。测定血清NGAL水平、肾小球滤过率(GFR)、血肌酐(Scr)水平,常规检测血脂水平。结果:T2DM组血清NGAL水平和GFR与对照组比较显著下降(P<0.05),TG、Scr与对照组比较显著上升;血清NGAL、TG水平和GFR为A组>B组>C组,三组间比较有显著性差异(P<0.05);血清Scr水平为A组<B组<C组,三组间比较有统计学差异(P<0.05)。T2DM患者血清NGAL水平与GFR、TG水平呈显著正相关(r=0.612,0.4510;P<0.05);血清NGAL水平与血清Scr水平呈显著负相关(r=-0.4120,P<0.05)。结论:T2DM并发肾损伤患者血清NGAL水平明显降低,且与肾损伤程度相关,因此,NGAL可以做为判定T2DM并发肾损伤的可靠指标。
AIM： To investigate the changes of neutrophil gelatinase-associated lipocalin（NGAL） in patients with diabetic nephropathy（DN） and its clinical significance.METHODS： 90 patients with T2DM and 30 healthy people were studied.90 patients of T2DM were divided into four groups according to 24-hour urinary albumi： A group,normal albuminuria group（24-hour uAlb30 mg）;B group,microalbuminuria group（24-hour uAlb 30-300 mg）;C group： macroalbuminuria group（24-hour uAlb300 mg）.The serum NGAL,GFR,Scr and TG levels were detected.RESULTS： The serum NGAL level and GFR of the T2DM group was significantly lower than control group（P0.05）,the TG and Scr level of the T2DM group was significantly higher than control group（P0.05）;Serum NGAL,TG and GFR of A group B group C group,three groups were significantly different（P0.05）;Serum Scr level of A group B groupC group,three groups were significantly difference（P0.05）;Serum NGAL level and GFR,TG levels were positively correlated（r=0.612,0.4510;P0.05）,serum NGAL level and Scr level was negatively correlated（r=-0.4120,P0.05）.CONCLUSION： The serum NGAL level of T2DM nephropathy is significantly lower,and significantly correlate with kidney damage.The serum NGAL level could be used a reliability index to judgment DN.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2010年第11期1113-1115,共3页
Chinese Journal of Cellular and Molecular Immunology
作者简介
作者简介：林忆阳（1977-），男，福建福清人，主治医师，博士Tel：0593-7165573：E—mail：firstaru@yeah．net
