摘要
胰腺内分泌肿瘤实质上是胃肠胰腺神经内分泌肿瘤家族成员,起源于胃肠、胰腺的神经内分泌干细胞,可分泌多种激素及胺类物质。根据肿瘤是否伴随激素相关性临床症状可分为功能性胰腺神经内分泌肿瘤、非功能性胰腺神经内分泌肿瘤。前者因有内分泌激素症状易于诊断,而后者易于胰腺癌及其他恶性肿瘤混淆,延误诊断及治疗。胰腺内分泌肿瘤的手术治疗效果好,即使是恶性胰腺内分泌肿瘤,积极治疗也可获得长期存活,但此类肿瘤容易误诊,临床上应予高度重视。近年来随着临床实践经验的积累和对胰腺内分泌肿瘤疾病本质的认识,胰腺神经内分泌肿瘤诊断率逐年增加,有关胰腺神经内分泌肿瘤的治疗手段、预后等方面的认识在不断更新。
Pancreatic neuroendocrine tumors （PETs）,as a member of Gastroenteropancreatic neuroendocrine tumors, were fairly rare neoplasms which origin was considered to be the neuroendocrine cells secreting multiple hormones and amines substance. According to the symptoms related to the secreting hormones, the PETs were divided into two subgroups： functional PETs which could be diagnosed easily according to their distinct clinical manifestation related to the secreting hormones ,and nonfunctional PETs which were often misdiagnosed with pancreatic cancer and other malignant tumors. The surgical resection of PETs could supply long time survival for patients that encouraged aggressive surgical procedure for treatment of PETs, and even for the malignant PETs and metastatic PETs. With much more accumulation of clinical practices and knowledge of entity of PETs, there was great improvement in the diagnosis, management, therapeutic approaches and prognosis for PETs.
出处
《中国实用外科杂志》
CSCD
北大核心
2010年第9期739-742,共4页
Chinese Journal of Practical Surgery
基金
上海市科学技术委员会重点项目[胰腺癌早期综合诊治技术体系的优化研究(编号:08411954300)]
关键词
胰腺
神经内分泌肿瘤
鉴别诊断
pancreas
neuroendocrine tumor
differential diagnosis
作者简介
通汛作者：傅德良，E-mail：surgeonfu@yaoo．com.cn
