摘要
目的:研究复方苦参注射液对进展期乳腺癌患者术前化疗缓解率、生存时间的影响,以及对化疗的减毒作用。方法:进展期乳腺癌患者共92例,随机分为两组,其中治疗组48例,对照组44例。治疗组患者在术前、术后化疗的同时给予复方苦参注射液,对照组仅给予化疗,观察两组患者的术前化疗缓解率、生存时间,以及化疗的急性毒性反应。结果:在化疗急性毒性反应方面,两组的骨髓抑制情况、消化道症状、肾脏毒性、心脏毒性及肝脏毒性等方面均未显示有统计学意义(P>0.05)。治疗组完全缓解率为6%(3/48),部分缓解率为75%(36/48),对照组完全缓解率为7%(3/44),部分缓解率为75%(33/44),均无统计学意义(P>0.05)。治疗组3年总体生存率为91%(41/45),无瘤生存率为77%(35/45),5年总体生存率为79%(33/42),无瘤生存率为76%(32/42),对照组3年总体生存率为88%(37/42),无瘤生存率为83%(35/42),5年总体生存率为80%(32/40),无瘤生存率为80%(32/40)。两组对比,5年无瘤生存率有统计学意义(P<0.05),其余各指标无统计学意义(P>0.05)。结论:复方苦参注射液对于进展期乳腺癌患者术前、术后化疗并无明显减毒作用,对其术前化疗缓解率、3年总体生存率及无瘤生存率、5年总体生存率亦无确切影响,但提高改善进展期乳腺癌患者的5年无瘤生存率。
OBJECTIVE：To evaluate the effect of Composite Kusheng Injection on the remission rate in preoperative chemotherapy,survival time,and its attenuation effect on chemotherapy in patients with progressive-phase breast cancer.METHODS：A total of 92 patients with progressive-phase breast cancer were randomly assigned to receive Composite Kusheng Injection in addition to chemotherapy before and after operation（treatment group,n = 48） or to receive chemotherapy alone（control group,n = 44）.The remission rate in preoperative chemotherapy,survival time,and toxicity of the chemotherapy in the two groups were observed.RESULTS：There were no significant differences between the two groups regarding the chemotherapy-induced toxicity such as myelosuppression,toxic reactions in digestive system,nephrotoxicity,cardiotoxcity and hepatotoxicity（P 〉 0.05）.In the treatment group,the complete remission（CR） rate and partial remission（PR） rate were 6%（3 /48） and 75%（36/48）,respectively,as compared with 7%（3 /44） and 75%（33 /44）,respectively in control group,and the differences were non-significant between the two groups（P 〉 0.05）.The 3-year survival,3-year disease free survival（dfs）,5-year survival,and 5-year disease-free survival rate were 91%（41/45）,77%（35/45）,79%（33/42） and 76%（32/42）,respectively in the treatment group,as compared with 88%（37/42）,83%（35/42）,80%（32/40） and 80%（32/40）,respectively in the control group.There were significant differences in 5-year survival between the two groups（P 〈 0.05）,whereas no significant differences were noted for all the other indexes（P 〉 0.05）.CONCLUSION：Composite Kusheng Injection showed insignificant attenuation effect on the chemotherapy-induced toxicity before and after operation and nonsignificant impact on the 3-year survival rate,3-year disease-free survival and the 5-year survival for patients with progressive-phase breast cancer.However,it improves the 5-year disease free survival of these patients.
出处
《中国医院用药评价与分析》
2010年第10期913-914,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
复方苦参注射液
乳腺癌患者
临床应用
Composite kusheng injection
Progressive-phase breast cancer
Clinical use
作者简介
副主任医师。研究方向：乳腺癌的综合治疗。E—mail：dengqingde2008@163．com
