摘要
目的探讨大剂量尿激酶治疗脑室铸型血肿的疗效及安全性。方法 63例符合标准的双侧脑室铸型血肿患者,随机分为治疗组和对照组,对照组31例采用双侧侧脑室引流加脑室内注入1万U尿激酶治疗,治疗组32例采用双侧侧脑室引流加脑室内注入10万U尿激酶治疗。结果治疗组有效率81.25%、血肿完全清除时间(4.6±2.1)天;对照组有效率54.84%,血肿完全清除时间(7.7±2.3)天。两组比较差异均有统计学意义(P<0.05)。术后再出血率、颅内感染率、肺部感染率两组比较差异无统计学意义(P>0.05)。结论双侧侧脑室引流加大剂量尿激酶早期脑室内注入治疗方法效果满意,安全可靠,可在影像学严密监测下用于脑室铸型血肿患者的治疗。
Objective To investigate the efficacy and safety of high-dose urokinase in the treatment of casting intraventricular hematoma.Methods A total of 63 cases of casting intraventricular hematoma by bilateral ventricular drainage and intraventricular administration of different dosage of urokinase.The 31 bilateral casting intraventricular hematoma patients in control group underwent early bilateral ventricular drainage combined with intraventricular administration of 10 thousand units of urokinase.In treatment group,32 bilateral casting intraventricular hematoma patients underwent early bilateral ventricular drainage combined with intraventricular administration of 100 thousand units of intraventricular urokinase.Results There were significant differences between the two groups in curative effect and duration for completely removal of hematoma （P 0.05）.There were no significant differences between the two groups in the incidence of postoperative hemorhage and incidence of complocations （P 0.05）.Conclusion The therapy of bilateral lateral ventricle drainage combined with intraventricular injection of high dose of urokinase is satisfactory,safe and reliable for casting intraventricular hematoma.
出处
《实用医院临床杂志》
2010年第6期80-81,共2页
Practical Journal of Clinical Medicine
关键词
脑室铸型血肿
脑室引流
尿激酶
治疗
疗效
Casting intraventricular hematoma
Ventricular drainage
Urokinase
Treatment
Curative effect
