期刊文献+

依托咪酯诱导全麻经口插管的临床观察 被引量:2

在线阅读 下载PDF
导出
摘要 目的采用双频指数(BIS)和熵(Entropy)观察全麻中依托咪酯诱导时的镇静、催眠作用。方法选择未用术前用药、ASAⅠ~Ⅱ级腹部手术患者30例随机分为3组,分别静脉注射(〉30 s)依托咪酯0.2、0.3、0.4 mg/kg,持续监测BIS和熵指数,当反应熵(RE)、状态熵(SE)、BIS为60、50、50时给予顺式阿曲库铵0.15 mg/kg(3倍ED95)行气管插管。比较各组睫毛反射消失的时间,RE、SE、BIS为60、50、50的时间及可行插管的时间。结果除3例患者外,其余患者在RE、SE、BIS减低到60、50、50时均可顺利进行气管插管且无不自主运动。0.2、0.3、0.4 mg/kg组患者睫毛反射消失的时间为72 s、65 s和69 s,差异无显著性(P〉0.05);患者BIS降低到50的时间和到气管插管的时间组间无差异(P〉0.05)。结论给予依托咪酯后,达到某一脑电效应的可预测性较差。脑电监测可能有助于更好地判断临床麻醉深度。
出处 《徐州医学院学报》 CAS 2010年第10期638-640,共3页 Acta Academiae Medicinae Xuzhou
基金 南京市医学科技发展项目(ykk07104)
作者简介 通信作者,E—mail:mazhengliang1964@yahoo.com.cn
  • 相关文献

参考文献11

  • 1Van Hamme MJ,Ghoneim MM,Ambre JJ.Pharmacokinetics of etomidate,a new intravenous anesthetic[J].Anesthesiology,1978,49(4):274-277.
  • 2Arden JR,Holley FO,Stanski DR.Increased sensitivity to etomidate in the elderly:initial distribution versus altered brain response[J].Anesthesiology,1986,65(1):19-27.
  • 3王强,马正良,刘礼军,张马忠,桂勤芳,鲍方,何风勇,杨初华.频谱熵和双频指数用于测定依托咪酯血浆效应室平衡速率常数的比较[J].临床麻醉学杂志,2009,25(3):208-211. 被引量:12
  • 4Schwilden H,Schüttler J,Stoeckel H.Quantitation of the EEG and pharmacodynamic modelling of hypnotic drugs:etomidate as an example[J].Eur J Anaesthesiol,1985,2(2):121-131.
  • 5Schüttler J,Schwilden H,Stoeckel H.Infusion strategies to investigate the pharmacokinetics and pharmacodynamics of hypnotic drugs:etomidate as an example[J].Eur J Anaesthesiol,1985,2(2):133-142.
  • 6Zbinden AM,Petersen-Felix S,Thomson DA.Anesthetic depth defined using multiple noxious stimuli during isoflurane/oxygen anesthesia.II.Hemodynamic responses[J].Anesthesiology,1994,80(2):261-267.
  • 7Liu J,Singh H,White PF.Electroencephalographic bispectral index correlates with intraoperative recall and depth of propofol-induced sedation[J].Anesth Analg,1997,84(1):185-189.
  • 8Doenicke AW,Roizen MF,Kugler J,et al.Reducing myoclonus after etomidate[J].Anesthesiology,1999,90(1):113-119.
  • 9Kuizenga K,Wierda JM,Kalkman CJ,et al.Biphasic EEG changes in relation to loss of consciousness during induction with thiopental,propofol,etomidate,midazolam or sevoflurane[J].Br J Anaesth,2001,86(3):354-360.
  • 10Figueredo E,Garcia-Fuentes EM.Assessment of the efficacy of esmolol on the haemodynamic changes induced by laryngoscopy and tracheal intubation:a meta-analysis[J].Acta Anaesthesiol Scand,2001,45(8):1011-1022.

二级参考文献12

  • 1黄咏磊,周仁龙,张马忠,王珊娟,王祥瑞,杭燕南.罗库溴铵相关药代学和药效学参数的测定[J].临床麻醉学杂志,2006,22(12):904-906. 被引量:5
  • 2俞青 张马忠 王祥瑞.血浆效应室消除速率常数的意义和临床应用[J].上海交通大学学报(医学版),2006,26:53-55.
  • 3Minto CF, Schnider TW, Gregg KM, et al. Using the time of maximam effect site concentration to combine pharmacokinetics and pharmacodynamics. Anesthesiology, 2003,99 : 324-333.
  • 4Zhang MZ, Yu Q, Huang YL, et al. A comparison between bispectral index analysis and auditory-evoked potentials for monitoring the time to peak effect to calculate the plasma effect site equilibration rate constant of propofol, Eur J Anaesthesiol, 2007,24 : 876-881.
  • 5Munoz HR, Cortinez LI, lbacache ME,et al. Estimation of the plasma effect site equilibration rate constant (Ke0) of propofol in children using the time to peak effect: comparison with adults. Anesthesiology, 2004,101: 1269-1274.
  • 6Arden JR, Holley FO, Sranski DR. lneresing sensitivity to etomidate in elderly. Initid distnbution versus altered brain response. Anesthesiology, 1986,65 : 19-27.
  • 7Eilers H, Niemann CU. Clinically importment drug interactions with intravenous anaesthetics in older patients, Drugs Aging, 2003, 20: 969-980.
  • 8Patel S. Cardiovascular effects of intravenous anesthetics. Int Anesthesiol Clin, 2002,40:15-33.
  • 9Doenicke A, Roizen MF, Nebauer AE, et al. A comparison of two forrnutations for etomidate, 2-hydroxgpropyl-betacyclodextrin (HPCD) and propylene glycol. Anesth Analg, 1994,79:933-939.
  • 10Viertio-Oja H, Maja V, Sarkela M, et al. Description of the Entropy algorithm as applied in the Datex-Ohmeda S/5 Entropy Module. Acta Anaesthesiol Seand, 2004, 48: 154- 161.

共引文献11

同被引文献13

引证文献2

二级引证文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部