摘要
目的:探讨血清VEGF及sICAM-1在高白细胞急性白血病(HLAL)患者中的表达及其临床意义。方法:用ELISA法检测32例HLAL患者及20例非HLAL患者血清VEGF及sICAM-1的表达水平,同时选择20例健康查体者作为对照组。结果:治疗前后HLAL和非HLAL患者血清VEGF及sICAM-1水平显著高于对照组,HLAL组患者血清VEGF及sICAM-1水平高于非HLAL组患者,且血清VEGF及sICAM-1两间之间呈显著正相关。结论:血清VEGF及sICAM-1在HLAL患者中的异常表达可能在HLAL的发生、发展中发挥了重要作用,且两者存在一定的相关性。
Objective： To investigate the expression levels of serum VEGF and sICAM-1 and their clinical sig- nificances in patients with hyperleukocytic acute leukemia （HLAL）. Method： The serum levels of VEGF and sI- CAM 1 in 32 hyperleukocytic acute leukemia and 20 non hyperleukocytic acute leukemia were detected by ELISA, compared with 20 healthy persons as the control group. Result：The expressions of VEGF and sICAM-1 in patients with hyperleukocytie acute leukemia and non hyperleukocytic acute leukemia were significantly higher than those in control group, especially in hyperleukocytic acute leukemia. There was also a positive correlation between the level of VEGF and sICAM-1. Conclusion：Overexpressions of VEGF and sICAM-1 may play a key role in the genesis and progression of hyperleukocytic acute leukemia.
出处
《临床血液学杂志》
CAS
2010年第5期527-529,共3页
Journal of Clinical Hematology
作者简介
通信作者：李学亮，E—mail：lylxl@163．com
