摘要
目的采用正交实验法研究岩白菜素β-环糊精包合物制备的最佳工艺。方法运用饱和水溶液法制备岩白菜素β-环糊精包合物,并采用紫外分光光度法测定岩白菜素包合率,紫外光谱、红外光谱验证包合物。结果通过正交实验得到最佳制备工艺:岩白菜素与β-环糊精投料比为1:1,包合时间为1 h,包合温度为80℃,包合率可达92.19%。结论饱和水溶液法制备岩白菜素β-环糊精包合物工艺简单可行,适用于岩白菜素口服制剂的改进。
Objective To optimize the technology for preparing β-cyclodextrin inclusion compound of bergenin by orthogonal test. Methods The β-cyclodextrin inclusion compound of bergenin was prepared by using saturated aqueous solution.Ultraviolet spectrophotometry was applied to detect the content of bergenin,ultraviolet spectrum and infrared spectrum were applied to verify the inclusion complex. Results The optimum preparation process was at the feed ratio of bergenin and β-cyclodextrin 1：1,for 1 hour inclusion at 80 ℃,then obtaing the inclusion rate as 92.19% by orthogonal test. Conclusion Saturated solution is of simple application in preparation of β-cyclodextrin inclusion compound of bergenin,and is suitable for improvement of bergenin oral preparation.
出处
《医药导报》
CAS
2010年第10期1337-1339,共3页
Herald of Medicine
作者简介
廖昌军（1981～），男，四川自贡人，实验师，硕士，从事实验中心药剂、药动学的实验教学和科研工作。电话：028-68289202，E-mail：liaocj009@yahoo．com。
