期刊文献+

核基质结合区结合蛋白质1(SATB1)在乳腺癌中的研究进展 被引量:1

在线阅读 下载PDF
导出
摘要 核基质结合区结合蛋白质1(special AT rich sequence binding protein,SATB1)是一种核基质结合区(matrix attachment regions MAR)结合蛋白质,它以其独特的模式识别并结合于核基质结合区上,参与染色质高级结构的形成和组织特异性基因的表达调控;并对胸腺细胞的发育和T细胞的成熟起到了尤为重要的作用。新近发现SATB1能促使乳腺癌细胞获得侵袭性表型,促进乳腺癌生长与转移;在侵袭转移过程中起关键作用。本文对近年来对SATB1在乳腺癌中的相关作用研究及进展作一综述。
作者 胡刚琴 张英
出处 《肿瘤预防与治疗》 2010年第5期444-446,440,共4页 Journal of Cancer Control And Treatment
作者简介 胡刚琴(1982-),女,湖北荆门人,住院医师,硕士研究生在读,研究方向:乳腺癌的基础与临床研究。
  • 相关文献

参考文献22

  • 1Yasui D,Miyano M,Cai S.SATB1 targets chromatin remodeling to regulate genes over long distances[J].Nature,2002,419(6907):641-645.
  • 2Pavan Kumar P,Prabhat Kumar Purbey,Chandan Kumar Sinha,et al.Phosphorylation of SATB1,a global gene regulator,acts as a molecular switch regulating its transcriptional activity in vivo[J].Molecular Cell,2006,22:231-243.
  • 3Iande Belle,Shutao Cai,Terumi Kohwi-Shigematsu.The genomic sequences bound to special AT-rich sequence-binding protein 1(SATB1) in vivo Jurkat T cells are tightly associated with the nuclear matrix at the bases of the chromatin loops[J].The Jour of Cell Biol,1998,141 (2):335-348.
  • 4Prabhat Kumar Purbey,Sunita Singh,Dimple Notani,et al.Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1[J].Molecular and Cellular Biology,2009,29(5):1321-1337.
  • 5Cai S,Han HJ,Kohwi-Shigematsu T.Tissue-specific nuclear architecture and gene expressiong regulated by SATB1[J].Nat Genet,2003,34(1):42-50.
  • 6Mai JC,Ellenbogen RG.SATB1:The convergence of carcinogenesis and chromatin conformation[J].Neurosurgery,2008,63(2):N6.
  • 7Tan JA,Sun Y,Song J,et al.SUMO conjugation to the matrix attachment region-binding protein,special AT-rich sequence-binding protein-1(SATB1),targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage[J].J Biol Chem,2008,283(26):18124-18134.
  • 8Alvarez JD,Yasui DH,Niida H,et al.The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development[J].Genes Dev,2000,14:521-535.
  • 9Dimple Notani,Kamalvishnu PG,Ranveer SJ,et al.Global regulator SATB1 recruits β-catenin and regulates TH2 differentiation in Wnt-dependent manner[J].PLoS Biology,2010,8(1):1-23.
  • 10Behrens J,Lustig B.The Wnt connection to tumorigenesis[J].Int J Dev Biol,2004,48(5-6):477-487.

同被引文献7

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部