摘要
目的:比较分析含奈达铂联合方案与含卡铂联合方案同期放化治疗Ⅳ期非小细胞肺癌(NSCLC)的疗效和不良反应。方法:经病理学和/或细胞学证实的Ⅳ期非小细胞肺癌42例,随机分成试验组(含奈达铂)20例(其中2例后期改为顺铂),对照组(含卡铂)22例(其中1例后期改为顺铂)。同期放化疗,化疗方案为紫杉醇或多西紫杉醇+奈达铂或卡铂,21天～28天/周期,2周期～4周期。放疗方法为三维适形后程加速超分割放疗,处方剂量为51Gy～76Gy。结果:试验组有效率((CR+PR)%)77.8%,对照组72.7%(P>0.05);试验组白细胞、血小板、血红蛋白下降、恶心呕吐、脱发发生率分别为72.2%、55.6%、50%、66.7%和72.2%,对照组分别为72.7%、50%、57.1%、57.1%和76.2%(P均>0.05),试验组Ⅲ度～Ⅳ度白细胞、血小板和血红蛋白下降发生率分别为5.6%、11.1%和5.6%,无Ⅲ度～Ⅳ度恶心呕吐;对照组分别为27.3%、27.3%、19.1%,Ⅲ度～Ⅳ度恶心呕吐发生率为4.8%(P均>0.05)。试验组有2例发生奈达铂过敏反应。结论:含奈达铂方案是治疗Ⅳ期NSCLC的有效方案,可取得与含卡铂方案相近的有效率及生存状况,在某些毒性反应方面显示出一定优势。
Objective： To evaluate the therapeutic effect and toxicity in NSCLC patients of stage Ⅳ treated with nedaplatin （NDP） plus paclitaxel or docetaxel and carboplatin（CBP） plus paclitaxel or docetaxel with concurrent radiotherapy. Methods： 42 NSCLC patients diagnosed by histology and/or cytology were randomized into two groups： the trial group （NDP） （n = 20） and the control group （CBP） （ n = 22）. The chemotherapy cycles were from 2 to 4,21 - 28 days per cycle. All patients were treated with latecourse accelerated hyperfractionated three-dimensional canformal radiation therapy. Results： The overall response rate （（ CR ＋ PR） % ） was 77.8% in NDP group and 72.7% in CBP group（ P 〉 0.05 ）. The incidence of leucopenia ,thrombocytopenla, hemoglobin decrease, nausea and vomiting and alopecia were 72.2% ,55.6% ,50% ,66.7% and 72.2%, respectively（ P 〉 0.05） in NDP group and 72.7% ,50%, 57.1% ,57.1% and 76.2% respectively （ P 〉 0.05 ） in CBP group. Rates of Ⅲ - Ⅳ grade leueopenia, thrombocytopenia and hemoglobin decrease were 5.6%, 11. 1% and 5. 6% respectively and in NDP group and 27.3% ,27.3% and 19. 1% （ P 〉 0.05 ） respectively in CBP group. Rates of Ⅲ - Ⅳ grade nausea and vomiting were 4.8% （ P 〉 0.05 ） in CBP group while zero in NDP group. There were 2 eases of allergic reactions to nedaplatin in NDP group. Conclusion： NDP combined with Paelitaxel or Docetaxel is effective for stage IV NSCL. When compared with similar regimen with CBP, the response rate and survival status are similar. NDP shows some superiority to CBP regards to some side effects.
出处
《肿瘤预防与治疗》
2010年第5期371-374,共4页
Journal of Cancer Control And Treatment
基金
贵州省科技攻关项目黔科合SY[2010]3078号
关键词
奈达铂
卡铂
顺铂
非小细胞肺癌
三维适形后程加速超分割放疗
Nedaplatin
Carboplatin
Cisplatin
Non-small-cell Lung Cancer
Late-course Accelerated Hyperfractionation Three-dimensional Conformal Radiation Therapy
作者简介
[作者简介]韩蕾（1978-），女，硕士，主治医师，主要研究方向：肿瘤放化综合治疗。
[通信作者]卢冰，教授，研究生导师，E-mail：lbgymaaaa@sohu．com
