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BMP4基因作为中国美利奴羊(军垦型)多胎性能候选基因的研究 被引量：5

Study of BMP4 as Candidate Genes for Prolificacy in Chinese Merino(Junken Type)
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摘要 以绵羊BMP4基因作为候选基因,以中国美利奴羊(军垦型)为研究对象,利用PCR-SSCP和基因测序分析BMP4基因5'UTR、外显子和3'UTR的单核苷酸多态性(SNPs),研究该基因对中国美利奴羊(军垦型)高繁殖力的影响。结果表明,BMP4基因5'UTR和外显子不存在多态性,3'UTR存在6个碱基(ACACAC)插入/缺失,最小二乘分析表明6 bp插入/缺失对绵羊高产羔数的影响差异不显著(P>0.05),提示检测的BMP4基因座对中国美利奴羊(军垦型)高繁殖力没有影响。 BMP4 genes were studied as candidate genes by PCR-SSCP and sequencing methods in order to find the association between different genotypes of SNPs with high prolificacy in Chinese Merino （JunKen Type）. The results showed that only a 6 bp insertion / deletion SNP （ACACAC） was detected in BMP4 3＇ UTR. LSM analysis showed no significant association was found between 6 bp insertion / deletion site with litter size in sheep（ P 〉 0.05 ）. These results indicated that BMP4 could not affect high prolificacy in Chinese Merino （JunKen Type）.
作者 杨华 杨永林 冯静 徐从祥 刘守仁
机构地区 新疆农垦科学院兵团绵羊繁育生物技术重点实验室
出处 《家畜生态学报》 2010年第4期10-13,共4页 Journal of Domestic Animal Ecology
基金 国家自然科学基金项目(30860187) 新疆生产建设兵团院士专项(2007JC20) 新疆生产建设兵团农业科技攻关(2009GG17)
关键词 中国美利奴羊(军垦型) BMP4基因 多胎 单核苷酸多态性 Chinese Merino （JunKen Type） BMP4 gene prolificacy SNPs
分类号 S811.5 [农业科学—畜牧学]
作者简介 杨华（1977-），男，新疆石河子人，博士，副研究员，研究方向：动物遗传育种与繁殖。E-mail：yhxjcn@sina．com
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参考文献14

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二级参考文献8

  • 1Piper L R, Bindon B M, Davis G H.The single gene inheritance of the high litter size of the Booroola Merino.Genetics of Reproduction in Sheep.R B Land and D W Robinson (eds).Butterworths, London,1985, 115～125.
  • 2Souza C J, MacDougall C, MacDougall C, Campbell B K, McNeilly A S, Baird D T.The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene.J Endocrinol, 2001, 169 (2):R1～6.
  • 3Mulsant P, Lecerf F, Fabre S, Schibler L, Monget P, Lanneluc I, Pisselet C, Riquet J, Monniaux D, Callebaut I, Cribiu E, Thimonier J, Teyssier J, Bodin L, Cognie Y, Chitour N, Elsen J M.Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Merino ewes.Proc Natl Acad Sci USA, 2001, 98(9):5104～5109.
  • 4Davis G H, McEwan J C, Fennessy P F, Dodds K G, Farquhar P A.Evidence for the presence of a major gene influencing ovulation rate on the X chromosome of sheep.Biol Reprod, 1991, 44(4):620～624.
  • 5Galloway S M, McNatty K P, Cambridge L M, Laitinen M P, Juengel J L, Jokiranta T S, McLaren R J, Luiro K, Dodds K G, Montgomery G W, Beattie A E, Davis G H, Ritvos O.Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner.Nat Genet,2000, 25(3):279～283.
  • 6Soyun E Y, Phlip S L, Byeong S Y, Jean Y C C, John K H L, Karen M Y.The type I BMP receptor BmprIB is essential for female reproductive function.Proc Natl Acad Sci USA, 2001, 98(14): 7994～7999.
  • 7Shimasaki S, Zachow R J, Li D, Kim H, Iemura S, Ueno N, Sampath K, Chang R J, Erickson G F.A functional bone morphogenetic protein system in the ovary.Proc Natl Acad Sci USA, 1999, 96: 7282～7287.
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共引文献42

同被引文献58

引证文献5

二级引证文献10

家畜生态学报
2010年 第4期

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