摘要
目的探讨埃索美拉唑、阿莫西林及克拉霉素联合应用治疗幽门螺旋杆菌（HP）阳性的胃十二指肠溃疡的临床效果。方法将2008年1月-2009年6月间在我院住院治疗的HP阳性的胃十二指肠溃疡患者50例，随机分为观察组和对照组，观察组给予埃索美拉唑、阿莫西林及克拉霉素联合应用治疗，对照组给予奥美拉唑、阿莫西林及左氧氟沙星联合应用，观察疗效。结果治疗组总有效率为96．00％，对照组为80．00％，两组比较差异具有显著性IP〈0．05）。治疗组疼痛消失时间为（1．56±0．25）d，对照组为（2．34±0．24）d，治疗组疼痛消失时间明显短于对照组，两组比较差异具有显著性垆〈0．05）。治疗组HP根除率为94．74％，对照组为89．47％，两组比较差异无显著性（P〉0．05）。两组在治疗过程中均未发生明显的不良反应。结论埃索美拉唑、阿莫西林及克拉霉素联合应用治疗HP阳性的胃十二指肠溃疡效果更好，值得应用。
Objective To explore the efficacy of two different therapies for HP-positive patients with gastroduodenal ulcers. Methods 50 patients who had been hospitalized from January 2008 to June 2009 were randomly assigned to receive triple therapy with esomeprazole, amoxicillin, and clarithromycin （study group）, or rabeprazole combined with amoxicillin and levofloxacin （control group）. Results The total effective rate differed significantly between the study group and the conlrol group （96.00% vs. 80.00%, P〈 0.05）. The time to pain relief was markedly shorter in the study group tha in the control group （P〈0.05）. The eradication rate did nof differ significantly between the two group （P〉0.05）. No obvious adverse reactions were found in the two groups. Conclusions Triple therapy with esomeprazole, amoxicillin, and clarithromycin is more effective in the treatment of HP-positive patients with gastroduodenal ulcers and is worth popularizing.
出处
《国际医药卫生导报》
2010年第17期2099-2101,共3页
International Medicine and Health Guidance News
