摘要
目的探讨心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)和肌红蛋白(MB)定量分析对急性心肌梗死诊断的临床价值。方法对96例急性心肌梗死(AMI)患者胸痛发作后24h内定量检测血清cTnI、CK-MB、MB浓度,比较它们对AMI诊断的敏感性和特异性。结果急性AMI患者的cTnI、CK-MB、MB的检测结果分别为(7.17±6.32)μg/L、(93±45)IU/L和(593±218)μg/L,较正常对照组均有显著性升高(P<0.05)。cTnI、CK-MB、MB对AMI的敏感性分别为97.9%、78.1%和100%,特异性分别为97.5%、95.8%和87.5%。结论急性AMI患者的cTnI、CK-MB、MB值均明显升高。CK-MB、MB在AMI诊断中具有较高的灵敏度和特异性,cTnI具有很高的灵敏度和特异性。cTnI是诊断AMI最好指标,为梗死诊断提供必要的信息。
Objective To explore the clinical significance of cTnI,CK-MB and MB in the early diagnosis of acute myocardial infarction（AMI） of patients.Methods cTnI,CK-MB and MB of 96 patients with AMI were detected within 24h after chest pain,and the specificity and sensitivity of them were compared in the early diagnosis of AMI.Results The serum concentration of cTnI,CK-MB and MB were （7.17±6.32）μg/L,（93±45）IU/L and （593±218）μg/L in patients with AMI,which were significantly higher than that of the control group（P〈0.05）.The sensitivity of cTnI,CK-MB and MB were 97.9%,78.1% and 100%,while the specificity of cTnI,CK-MB and MB were 97.5%,95.8%and 87.5% respectively.Conclusion The serum concentration of cTnI,CK-MB and MB in patients with AMI were significantly higher than that of the control group.And CK-MB and MB have high specificity and sensitivity in the early diagnosis of AMI,and cTnI was the best index to diagnose of AMI because of its sensitivity and specificity.
出处
《检验医学与临床》
CAS
2010年第17期1827-1828,共2页
Laboratory Medicine and Clinic
