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精子因素对不明原因复发性流产的影响 被引量:10

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摘要 目的:探讨不明原因复发性流产患者配偶精子DNA碎片的发生比例及其原因。方法:精子染色质扩散(SCD)实验分析精子DNA碎片,苯胺蓝染色法评价精子核成熟度,检测不明原因复发性流产患者60例(复发流产组)。以生育健康成年男性52例为对照组。结果:复发流产组SCD小光晕和无光晕精子(精子DNA碎片)比值平均为(26.7±10.6)%,明显高于对照组(11.9±5.9)%,P<0.001,而大光晕和中光晕精子比值复发流产组明显低于对照组(P<0.001);复发流产组苯胺蓝染色阳性率(35.6%)明显高于对照组(8.9%)。结论:复发流产组患者精子DNA碎片比例增高可能与精子核成熟度异常有关。
出处 《实用医学杂志》 CAS 北大核心 2010年第17期3142-3144,共3页 The Journal of Practical Medicine
基金 中国博士后基金项目(编号:20090460816)
作者简介 曹晓敏为广东省中山市人民医院妇产科在站博士后. 通信作者:林仲秋E-mail:linzhongqiu@hotmail.com
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参考文献6

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二级参考文献9

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