摘要
脑血管痉挛（cerebral vasospasm,CVS）是蛛网膜下腔出血（subaraachnoid hemorrhage,SAH）后一种常见的灾难性的并发症,其所致迟发性缺血性神经功能损害是造成患者致残和死亡的最主要原因.虽经多年研究,但其发病机制至今尚未完全阐明.一氧化氮、内皮素-1、血红蛋白氧化产物及炎症反应均被认为参与致病过程.针对这些发病机制的治疗措施目前仍处于研究阶段,预期会在今后的脑血管痉挛的防治中发挥重要作用.
Cerebral vasospasm serves as a severe complication in patients who experience subarachnoid hemorrhage. The following delayed ischemic neurological deficits is the leading preventable cause of death and disability. Despite the potentially devastating consequences of cerebral vasospasm, the mechanisms underlining are incompletely understood. Nitric oxide, endothelin-1, bilirubin oxidation products and inflammation appear to be involved in its pathogenesis. Therapies directed at many of these mechanisms are currently under investigation and hold significant promise for an ultimate solution to this substantial problem.
出处
《国际麻醉学与复苏杂志》
CAS
2010年第4期338-342,共5页
International Journal of Anesthesiology and Resuscitation
基金
北京市委组织部优秀人才培养基金（20031D0300413）
北京市科委科技新星计划项目（2007B74）
