摘要
目的探讨与先天性心脏病（CHD）发生有关的危险因素。方法采用分层按比例整群抽样的方法,在安徽省蚌埠市16 698名0-5岁儿童中筛查出86例CHD患儿。采用1∶1配对病例对照研究方法,对照者为同性别、出生时间相差不超过1个月的健康儿童。采用单因素及多因素Logistic回归分析进行CHD的危险因素分析。结果最终筛选出与CHD发生相关的4个危险因素,分别为母亲孕早期接触有毒化学物、孕早期呼吸道感染、有不良生育史、居住地附近有河流,其OR值分别为1.745、1.747、1.644和1.487。结论母亲孕早期接触有毒化学物或发生呼吸道感染、有不良生育史、居住地附近有河流是新生儿CHD的主要危险因素。
Objective To investigate the environmental risk factors associated with the development of congenital heart diseases（CHD）. Methods Eighty-six children with CHD were screened from 16 698 children aged between 0 to 5 years in Bengbu,Anhui Province by stratified cluster sampling.A population-based 1∶1 matched case-control study was conducted,and each case was matched with one normal control by gender and birth date（with difference no more than one month）.The risk factors of CHD were analysed by univariate and multivariate Logistic regression analysis. Results Four risk factors were screened to be associated with the development of CHD,including maternal exposure to poisonous chemicals during first trimester of pregnancy（OR,1.745）,maternal respiratory infection during first trimester of pregnancy（OR,1.747）,abnormal childbearing history（OR,1.644）and river around the dwelling place（OR,1.487）. ConclusionMaternal exposure to poisonous chemicals and maternal respiratory infection during first trimester of pregnancy,as well as abnormal childbearing history and river around dwelling place are major environmental risk factors contributing to CHD in neonates.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第8期894-896,901,共4页
Journal of Shanghai Jiao tong University:Medical Science
基金
安徽省教育厅自然科学基金(KJ2007B334ZC)
安徽省计生委基金(05-02)~~
作者简介
芈静（1976-），女，讲师，硕士生；电子信箱：xiaomi05011@sina．com。
