摘要
目的探讨葡萄糖运转蛋白-1(Glut-1)和增殖细胞核抗原(PCNA)在子宫内膜癌发生发展中的作用。方法采用免疫组化SP法检测20例正常增生期子宫内膜、25例子宫内膜单纯增生、25例子宫内膜不典型增生、40例子宫内膜腺癌组织中Glut-1和PCNA的表达。结果 Glut-1和PCNA在子宫内膜癌和不典型增生子宫内膜中的表达明显高于正常增生期子宫内膜,差异有统计学意义(P<0.05),进一步分析显示二者的高表达与子宫内膜癌的组织分化程度有关(P<0.05),而与临床分期无关(P>0.05),且二者在子宫内膜癌组织中的表达呈正相关(r=0.544,P<0.05)。Glut-1在子宫内膜单纯增生和子宫内膜不典型增生中的表达差异有统计学意义(P<0.05),在高分化与低中分化子宫内膜癌中的表达差异亦有统计学意义(P<0.05)。结论 Glut-1和PCNA的异常表达可能在子宫内膜的恶性转变和细胞分化中发挥着重要的作用,Glut-1可能有利于鉴别子宫内膜单纯增生与子宫内膜不典型增生、高分化与低中分化子宫内膜癌。
Objective To investigate the expression of Glut-1 and PCNA in endometrial adenocarcinoma and precancerous lesion.Methods Immunohistochemical staining SP method was used to detect the expression of Glut-1 and PCNA in 20 cases of normal proliferative endometrium,25 cases of endometrial hyperplasia,25 cases of atypical endometrial hyperplasia,and 40 cases of endometrial adenocarcinoma.Results The expressions of Glut-1 and PCNA in endometrial adenocarcinoma and atypical endometrial hyperplasia were significantly higher than normal proliferative endometrium（P0.05）.Further study showed that there are relationships between their expressions and cell differentiation in endometrial adenocarcinoma（P0.05）,but no relation with the surgical pathological classification（P0.05）.Positive correlation was also found between Glut-1 and PCNA expression（r=0.544,P0.05）.There are significant differences between the expression of Glut-1 in endometrial hyperplasia and endometrial atypical hyperplasia （P0.05）,also in well differentiated and low differentiated endometrial adenocarcinoma（P0.05）.Conclusion Abnormal expression of Glut-1 and PCNA may contribute to the pathogenesis and development of the endometrial adenocarcinoma.Glut-1 may be helpful for differentiating endometrial hyperplasia and endometrial atypical hyperplasia, and well differentiated and low differentiated endometrial adenocarcinoma.
出处
《疑难病杂志》
CAS
2010年第9期671-673,共3页
Chinese Journal of Difficult and Complicated Cases
