摘要
目的调查上海地区高危人群铁缺乏症的患病率和危险因素；评价铁参数诊断缺铁的价值；铁剂治疗缺铁性贫血的费用效果。方法采用临床流行病学的研究方法，包括横断面调查、病例对照研究、诊断试验评价及费用效果分析。结果月经期妇女、妊娠妇女和青少年缺铁性贫血的患病率分别为１１．３９％，１９．２８％及９．８４％，缺铁的患病率分别为４３．４３％，６６．２７％及１３．１７％；主要的危险因素月经期妇女为月经过多，青少年为营养因素。ＲＯＣ曲线分析表明血清铁蛋白在诊断缺铁，血清可溶性转铁蛋白受体诊断慢性病贫血合并缺铁具有较高诊断价值。琥珀酸亚铁比硫酸亚铁控释片及力蜚能具有较好的费用效果。结论预防月经过多及营养不良可降低缺铁的患病率，在缺铁诊断中推荐血清铁蛋白和血清可溶性转铁蛋白受体，在缺铁治疗中推荐琥珀酸亚铁。
Objective To assess the prevalence and risk factors of iron deficiency(ID) among high risk population in Shanghai, and to evaluate the diagnostic utility of iron parameters and cost effectiveness of iron supplement in iron deficiency anemia (IDA). Methods Clinical epidemiological study methods included cross sectional study, case control study, diagnostic test evaluation and cost effectiveness analysis. Results The prevalences of IDA among menstruating women, pregnant women and adolescents were 11.39%, 19.28% and 9.84% respectively, and those of ID were 43.43%, 66.27% and 13.17% respectively. The main risk factors were menorrhagia and nutritional deficiency. ROC curve analysis showed that iron parameters of high diagnostic value were ferritin for ID and sTfR for ACD with ID and ferrous succinate had better cost effectiveness than Ferriod and Niferex. Conclusion Prevention of menorrhagia and malnutrition can reduce the prevalence of ID. SF and sTfR are recommeded for the diagnotics for ID and ferrous succinate good for treatment.
出处
《上海医学》
CAS
CSCD
北大核心
1999年第2期74-77,共4页
Shanghai Medical Journal
关键词
缺铁性贫血
贫血
患病率
铁蛋白
琥珀酸亚铁
Iron deficiency anemia Prevalence Serum ferritin Serum transferrin receptor Ferrous succinate
