摘要
目的:观察早期肠内营养(EEN)支持对重型颅脑外伤病人肺部感染的预防疗效。方法:选择青壮年重型颅脑外伤60例,随机分为EEN组和对照组。EEN组在伤后或术后12～24 h内给予EN,对照组在伤后或术后24 h～5 d给予EN,利用双糖试验法测定两组病人的肠黏膜屏障功能,观察病人肺部感染发生时间等临床指标。结果:EEN组病人伤后第7天乳果糖/甘露醇比值明显低于对照组,病人平均体温、肺部感染发生率也低于对照组,按照ADL评分法,EEN组病人的恢复期日常行为能力明显好于对照组。结论:EEN可改善重型颅脑外伤病人的肠黏膜屏障功能,减少肺部感染的发生率,有利于病人的康复。
Objective： To investigate the prophylactic effect of EEN on pulmonary infection in patients with severe traumatic brain injury.Methods： 60 cases of young adults with severe brain injury were randomized into the early enteral nutrition group（experimental group） or the control group.The experimental group was feeded 12～24 hours after injury or surgery and the control group was feeded 24 h～5 d after injury or surgery.The double-sugar test method was used for determination of intestinal barrier function,and the duration of pulmonary infection was recorded.Results： The lactulose/mannitol ratio in experimental group was significantly lower than in control group on the 7th postoperative day.The average body temperature and duration of pulmonary infection in experimental group were significantly lower than in control group.According to ADL scores,the daily capacity of convalescent patients in experimental group was significantly better than in control group.Conclusion： The early enteral nutrition can improve mucosal barrier function,reduce the incidence of pulmonary infection and improve overall prognosis in patients with severe traumatic brain injury.
出处
《肠外与肠内营养》
CAS
北大核心
2010年第4期206-208,211,共4页
Parenteral & Enteral Nutrition
关键词
重型颅脑外伤
肠内营养
肺部感染
肠黏膜屏障
Severe traumatic brain injury
Enteral nutrition
Pulmonary infection
Mucosal barrier
作者简介
冯毅，主治医师，医学硕士，从事脑外伤及脑血管病的基础与临床研究。
通讯作者：蔡学见，E-mail：caixuejian@163．com
