摘要
目的探讨沙眼衣原体（ＣＴ）感染与输卵管妊娠（ＴＰ）之间的关系及其发病机制，并试图找到预防和降低ＴＰ发生的方法和途径。方法分别采用聚合酶链反应（ＰＣＲ）技术、酶联免疫吸附（ＥＬＩＳＡ）测定ＴＰ患者宫颈、输卵管组织中的ＣＴＤＮＡ及其血清中的特异性ＣＴＩｇＧ。结果ＴＰ患者宫颈ＣＴＤＮＡ和血清ＣＴＩｇＧ检出均显著高于对照组（Ｐ＜００５，Ｐ＜００１）；ＴＰ患者的输卵管组织中ＣＴＤＮＡ阳性与组织学浆细胞分级有关（ｒ＝０５，Ｐ＜００５）。且ＴＰ患者血清ＣＴＩｇＧ阳性与患者盆腔粘连和既往盆腔炎病史（ＰＩＤ）有关（Ｐ＜００１，Ｐ＜００５）。结论ＣＴ感染与ＴＰ的发生有着紧密的联系。通过ＰＣＲ方法对宫颈ＣＴ感染进行筛查和治疗，有望降低ＴＰ的发生。
Objective\ To investigate the relationship between chlamydia trachomatis(CT)infection and tubal pregnancy(TP)and evaluate some factors which can possibly reduce the incidence of tubal pregnancy.Methods\ CT DNA was determined in cervical and fallopian tubal tissue by polymerase chain reacton(PCR),and serum CT IgG was determined by enzyme-linked immunosorbent assay(ELISA)in women with tubal pregnancy.Results\ CT DNA in cervical ephithelial cells and serum CT IgG were found to be significantly higher in TP group than those in control group.Positive CT DNA in fallopian tubal tissues was correlated with plasma cell infiltration in women with TP and the pelvic damage and previous pelvic inflammatory disease(PID)were associated with positive serum CT IgG among women with TP.Conclusions\ CT infection was corrrelated with TP.It is possible to reduce the incidence of TP by screening and treating for cervical CT infection by PCR technique.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
1999年第3期163-165,共3页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
异位妊娠
输卵管妊娠
沙眼衣原体
Pregnancy,tubal\ Chlamydia trachomytis\ Polymerase chain reaction\ Enzyme linked immunosorbent assay\ Histology
