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某些胆酸及去氧胆酸肟类化合物的合成 被引量：2

Synthesis of some cholic acid and deoxycholic acid oximes
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摘要 从胆酸和去氧胆酸出发,经过不同反应,将甾核以及支链上的取代基分别转化为羰基及酯基,然后和盐酸羟胺反应引进肟基,合成了六个新的甾体肟类化合物：7-羟基-12-氧代-3-肟基胆酸甲酯（5）、7,12-二氧代-3-肟基胆酸甲酯（6）、12-氧代-3,7-二肟基胆酸甲酯（7）、3,7,12-三肟基胆酸甲酯（8）、12-氧代-3-肟基去氧胆酸甲酯（12）、3,12-二肟基去氧胆酸甲酯（13）。通过NMR和IR对合成物5~10的结构进行了表征。 The carboxyl and hydroxys of cholic acid and deoxycholic acid were transformed into the carbonyl and esteryl by a series of reactions.Six steroidal oximes were synthesized by the oximation using hydroxylammonium chloride.They were methylester 7-hydroxy-12-keto-3-hydroximinocholic acid（5）,methylester 7,12-diketo-3-hydroximinocholic acid（6）,methylester 12-keto-3,7-dihydroximinocholic acid（7）,methylester 3,7,12-trihydroximinocholic acid（8）,methylester 12-keto-3-hydroximinodeoxycholic acid（12）and methylester 3,12-dihydroximinodeoxycholic acid（13）.The structures of 5~10 were characterized by NMR and IR.
作者 陈思静 张晓佳 贾琳怡 崔建国
机构地区 广西师范学院化学与生命科学学院
出处 《化学研究与应用》 CAS CSCD 北大核心 2010年第7期848-852,共5页 Chemical Research and Application
基金 国家自然科学基金(No.20562001) 广西自然科学基金(No.0832106) 广西教育厅科研基金(No.200707MS172)资助项目
关键词 胆酸 去氧胆酸 甾体肟类化合物 合成 cholic acid deoxycholic acid steroidal oximes synthesis
分类号 O629.29 [理学—有机化学]
作者简介 联系人简介：崔建国（1954-），男，教授，主要研究方向：有机合成、药物合成、甾体化学。Email：euijg1954@126．com
  • 相关文献

参考文献14

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共引文献20

同被引文献33

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化学研究与应用
2010年 第7期

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