摘要
目的评价厄贝沙坦联合索他洛尔治疗阵发性心房纤颤的效果。方法将102例阵发性心房颤动的患者分为治疗组和对照组,均给予索他洛尔治疗,治疗组加用厄贝沙坦,疗程均为1年。比较两组治疗后第3、6、12个月的窦性心律维持率和左心房内径。结果治疗后第3、6个月治疗组窦性心律的维持率分别为80%和73%,高于对照组的78%和69%,但两组间比较差异无统计学意义(P>0.05),而治疗12个月后,治疗组的窦性心律维持率为73%,对照组为51%,两组间比较差异有统计学意义(P<0.05)。治疗前、治疗后第12个月的左心房内径治疗组为39.2±5.0mm;对照组为41.1±1.9mm,两组治疗12个月后左心房内径比较差异有统计学意义(P<0.05)。结论厄贝沙坦联合索他洛尔转复阵发性心房颤动,预防心房颤动发作的疗效显著优于单用索他洛尔,并有延缓左心房扩大的作用。
ObjectiveTo investigate the effect of combination of irbesartan and sotalol in patients with paroxysmal atrial fibrillation. Methods102 patients with paroxysmal atrial fibrillation were randomly divided into 2 groups：group I （Irbesartan plus sotalol group,n=46）and group Ⅱ （sotalol group,n=46）. After 12 month follow-up,the maintenance rate of sinus rhythm was measured in the 3rd, 6th, and 12th months,and the left atrial diameter was measured before the treatment and 3rd, 6th, and 12th months after the treatment. ResultsThere was no difference in the maintenance rate of sinus rhythm between group I and group Ⅱ in the 3rd and 6th month. The maintenance rate of sinus rhythm in group I was 73% in the 12th month, and the rate in the group Ⅱ was 51%. They had significant difference（P〈0.05）.At 12 months after the treatment,the left atrial diameter in group Ⅱ was significantly larger than that of group I（P〈005）. ConclusionThe combination of irbesartan and sotalol is more effective than sotalol alone for sinus rhythm maintenance and may restrain the enlargement of the left atrium.
出处
《医学研究杂志》
2010年第7期68-70,共3页
Journal of Medical Research
作者简介
通讯作者：陈海燕，电子信箱：ducky．chy@163．com
