摘要
目的探讨支气管镜介入辅助治疗配合全身抗结核治疗对耐多药空洞肺结核(MDR—PTB)的治疗效果。方法将60例耐多药空洞肺结核患者随机分为治疗组(30例)和对照组(30例),两组均采用3DVAE克拉/15DVE克拉全身抗结核治疗,治疗组强化期每周经支气管镜治疗1次,共5～8次,然后比较两组的临床疗效。结果治疗3、6个月时,在痰菌阴转率、病灶吸收率(显著吸收+吸收)、空洞缩小或闭合率方面两组比较差异有显著性(P<0.05)。结论经支气管镜介入辅助治疗配合全身抗结核治疗耐多药空洞肺结核,疗效显著优于单纯全身抗结核治疗,其有促使痰菌阴转、病灶吸收及空洞缩小或闭合的作用。
[Objective]To study the efficacy of bronchofiberscope intervention combined with chemotherapy in the treatment of multi-drug resistant pulmonary tuberculosis （MDR-PTB）. [Method]60 cases of MDR-PTB patients were randomly divided into the treatment group （30 cases） and the control group （30 cases）. Both groups received the 3DVCAE/15DVEC treatment, while the treatment group were also treated by injecting drugs through bronchofibemcope once every week during the enhanced period. Then the comparisons were made between the two groups in the curative effects. [Results]By the end of 3 and 6 months, there were significant differences between the two groups in the sputum tubercle bacillus conversion rate, radiographic improvement rate and cavity closing rate （P 0.05）.[Conclusion]Bronchofiberscope intervention combined with chemotherapy is more effective than simple chemotherapy in the treatment of MDR-PTB, which provides the significant effect on the closing of the cavity and turning sputum negative.
出处
《中国内镜杂志》
CSCD
北大核心
2010年第6期638-640,共3页
China Journal of Endoscopy
基金
广州市医药卫生科技项目(2007-YB-223)
关键词
肺结核
抗药性
支气管镜
tuberculosis
drug resistant
bronchofiber scope
