摘要
目的研究慢性肺心病患者内皮素(ET)、血栓素B2(TXB2)和6-酮-前列腺素Flα(6-K-PGFlα)的变化及其临床意义。方法慢性肺心病患者72例,其中男42例、女30例。功能代偿期48例、功能失代偿期24例,年龄(55.6±8.9)岁。另选献血者32例作为正常对照。采用放免法测定血浆ET,TXB2和6-K-PGFlα。结果所有患者均有肺功能异常。与正常对照比较,无论慢性肺心病是功能代偿期还是功能失代偿期患者,血浆ET和TXB2均明显升高(P<0.01),而6-K-PGFlα则明显下降(P<0.01),但功能代偿期和功能失代偿期之间血浆ET,TXB2和6-K-PGFlα变化无差异(P>0.05);血浆ET和TXB2升高与6-K-PGFlα降低呈负相关(r=-0.4571,P<0.05)。结论慢性肺心病患者血浆ET,TXB2和6-K-PGFlα可发生明显改变,这一变化对研究慢性肺心病有一定的临床意义。
Objective To explore the changes of the neurotransmitters in patients with chronic pulmonary heart disease（CPHD） and its clinical significance.Methods Seventy-two patients with CPHD（42 males,30 females,mean age 55.6±8.9 years） were enrolled in the study,including 48 patients with compensated CPHD and 24 with uncompensated CPHD.Plasma endothelin（ET）,thromboxance B2（TXB2） and 6-keto-prostaglandin F1 alpha（6-K-PGFlα） were detected by radioimmunoassay.Thirty blood donors were selected as the normal control.Results Compared with the normal controls,CPHD patients showed abnormal pulmonary function,and significantly elevated levels of plasma ET and TXB2（P0.01） and lowered 6-K-PGFlα（P0.01）,but no significant differences were found between the patients with compensated CPHD and uncompensated CPHD（P0.05）.Plasma ET and TXB2 levels were inversely correlated to 6-K-PGFlα level（r=-0.4571,P0.05）.Conclusion The patients with CPHD present with obvious changes of plasma ET,TXB2 and 6-K-PGFlα.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2010年第6期1244-1246,共3页
Journal of Southern Medical University
基金
国家自然科学基金(30770926)
关键词
肺心病
慢性
神经介质
内皮素
血栓素B2
6-酮-前列腺素Flα
chronic pulmonary heart disease
neurotransmitter
endothelin
thromboxance B2
6-keto-prostaglandin F1 alpha
作者简介
成涌（1964-），男，副主任医师，电话：0911-8882009，E-mail：lisaxw@163．com
通讯作者：李志奎（1963-），博士，教授，主任医师，电话：029-84775237，E—mail：lizhikui@hotmail．com
