摘要
目的:探讨氟康唑预防重症急性胰腺炎(severe acute pancreatitis,SAP)真菌感染的效果.方法:对符合要求的98例SAP进行对比临床研究,其中使用抗生素治疗,第7-12天预防性使用氟康唑抗真菌治疗者为治疗组(n=32),其余为对照组(n=66).治疗组在常规治疗的基础上加每日静脉点滴氟康唑200mg,连续5d,对照组仅给予常规治疗.观察两组患者的真菌感染发生率、病死率、住院时间和真菌感染发生时间.结果:治疗组与对照组的真菌感染率(9.4%vs27.3%,P<0.05)、病死率(0%vs12.1%,P<0.05),住院时间(28.3d±16.9d vs37.4d±22.3d,P<0.05)均明显低于对照组,真菌感染发生时间为明显晚于对照组(26.5d±9.3d vs14.4d±6.8d,P<0.05).结论:预防使用氟康唑可明显降低SAP患者的真菌感染发生率、病死率、缩短住院时间.
AIM：To investigate the prophylactic effect of fluconazol against fungal infection in patients with severe acute pancreatitis （SAP）. METHODS：Ninty-eight SAP patients treated at our hospital from January 2005 to December 2009 were divided into treatment group （n = 32） and control group （n = 66）. The treatment group underwent routine therapy plus intravenous fluconazol 200 mg once daily for 5 d,while the control group underwent routine therapy alone. The incidence and duration of fungal infection,mortality and the length of hospital stay were compared between the two groups. RESULTS：The incidence of fungal infection and mortality in the treatment group were lower than those in the control group （9.4% vs 27.3% and 0% vs 12.1%,respectively; both P 0.05）. The length of hospital stay in the treatment group was shorter than that in the con-trol group （28.3 d ± 16.9 d vs 37.4 d ± 22.3 d,P 0.05）. The duration of fungal infection in the treatment group was longer than that in the control group （26.5 d ± 9.3 d vs 14.4 d ± 6.8 d,P 0.05）. CONCLUSION：Fluconazol can significantly reduce the incidence of fungal infection,mortality and the length of hospital stay in SAP patients.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第15期1608-1611,共4页
World Chinese Journal of Digestology
关键词
氟康唑
真菌感染
重症急性胰腺炎
治疗
Fluconazol
Fungal infection
Severe acute pancreatitis
Treatment
作者简介
通讯作者：石承先，主任医师，550002，贵州省贵阳市宝山南路1号，贵州省人民医院肝胆外科chengxianl@yahoo.com．cn电话：0851—5937865
