摘要
目的对比观察静脉用尼卡地平与拉贝洛尔治疗严重妊娠期高血压疾病的降压效果及对孕妇血液动力学的影响。方法 100例妊娠高血压疾病患者,收缩压≥160mmHg和(或)舒张压≥110mmHg,随机分为静脉点滴尼卡地平组和拉贝洛尔组,根据血压每5分钟调整1次药物剂量直至达到预期理想血压(140～150/90～100mmHg)。用MP妊高征监测系统通过桡动脉记录患者用药前和用药后4～6小时心脏指数(CI)、外周阻力(TPR)变化。电子胎心监护仪、B超观察用药前用药后2小时胎心监护变化、脐动脉血流S/D值。结果达预期血压的时间尼卡地平组(13.14±2.46)分钟略短于拉贝洛尔组(18.41±15.99)分钟,但两组间无显著性差异(P>0.05)。结论除尼卡地平组观察到有轻度的心动过速发生外,均无严重不良反应发生,母婴耐受良好。
Objective To assess the efficacy and safety of intravenous nicardipine in comparision of labetalol in the acute management of severe hypertension in pregnancy. Methods We performed a randomized trail of intravenous nicardipine and labetalol in 100 peripartum patients with sustained sysytolic blood pressure of ≥ 160mmHg and/or diastolic blood pressure of ≥ 110mmHg. Both agents were repeated at sequentially escalating dosage every 5 minutes until a therapeutic goal （ 140 - 150/95 - 100mmHg） . Cardiac index （CI） and total peripheral resistance （TPR） were observed by MP PIH monitor system before and after treatment. Fetal heart rate and ultrasonic umbilical artery flows S/D value were observed to study the influence of nicardipine on fetus. Results The time to achieve the blood pressure goal was shorter with nicardipine（ 13.14 ± 2.46min） than with labetaM （ 18.41 ±15.99min）, but there is not significant difference（P 〉 0.05 ）. Conclusion Nicardipine and labetalol were well tolerated by the mother and the fetus, except for a moderate tachycardia observed with the use of nicardipine.
出处
《中国医刊》
CAS
2010年第7期45-47,共3页
Chinese Journal of Medicine
关键词
尼卡地平
拉贝洛尔
妊娠期高血压疾病
nicardipine
labetalol
pre-eclampsia severe hypertension in pregnancy
