摘要
【目的】分析原因不明性复发性流产患者基础性激素水平,探索不明原因复发性流产的内分泌因素。【方法】共收集143例就诊于我院复发性流产专科门诊的原因不明复发性流产患者的基础内分泌资料,将其与206例因男方因素行IVF治疗并已获得生育的患者的基础内分泌资料进行对照研究,分析两组患者的基础FSH、LH、PRL、E2、T水平的差异。所有患者年龄为25至40岁。【结果】原因不明复发性流产患者的基础FSH、PRL、LH、T水平与获得生育的对照组相比均无统计学差异,但是原因不明复发性流产组患者的基础雌激素水平明显高于对照组(P<0.01)。复发性流产次数2、3及4次患者的雌激素水平均明显高于对照组(P<0.05),但不同流产次数的各组之间无统计学差异。<30岁、30～35岁及>35岁的复发性流产患者组的雌激素水平均高于对照组(P<0.05),且>35岁患者的FSH也明显高于<30岁及30～35岁组(P<0.05),而对照组>35岁患者的FSH与<30岁及30～35岁组无差异(P>0.05)。【结论】不明原因复发性流产患者的基础内分泌异常提示患者存在卵巢功能早期衰退(POA),可能是不明原因复发性流产的重要病因之一。
【Objective】To explore the endocrine etiology of unexplained recurrent spontaneous abortion by determining the basal hormone levels in the patients with unexplained recurrent spontaneous abortion.【Methods】A total of 143 cases diagnosed unexplained recurrent spontaneous abortion were analyzed retrospectively.Compared with 206 cases who performed IVF-ET（in vitro fertilization and embryo transfer,IVF-ET）for male factors and succeeded in deliveries,basal FSH（follicle stimulation hormonal,FSH）,LH（luteining hormonal,LH）,PRL（prolactin,PRL）,E2（estradiol,E2）,and T（testosterone,T）between the two groups were compared.The age of all the cases was between 25 and 40 years old.【Results】There were no significant difference of basal FSH,PRL,LH,and T between the unexplained recurrent spontaneous abortion group and compared with control group,but the basal estrogen level was significantly higher in abortion group（P0.01）.The basal estradiol level in the patients with 2,3,and 4 times previous abortion were all significantly higher than the control group（P0.05）,however there were no difference among the patients with 2,3,and 4 times previous abortion.Basal estrogen levels of the30 years,30-35 years and30 years old patients in abortion groups were higher than that of the control group（P0.05）.Furthermore,FSH of the35 years old patients in the abortion group was significant high than the30 years and 30-35 years old patients（P0.05）.However,FSH in the control group showed no significant difference among the35 years old,the30 years and 30-35 years old patients（P0.05）.【Conclusion】The abnormality of basal hormone level in the patients with unexplained recurrent spontaneous abortion demonstrates premature ovarian aging（POA）might be one of the important etiology.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2010年第3期409-412,共4页
Journal of Sun Yat-Sen University:Medical Sciences
基金
广东省科技计划项目(2008B080703035)
关键词
复发性流产
基础性激素
雌激素
病因
recurrent spontaneous abortion
basal hormone
estrogen
etiology
作者简介
王琼，主任医师，硕士导师，E-mail：wangqionggz@yahoo．com．cn
