摘要
目的:探寻治疗化疗药物所致周围神经病变的有效疗法。方法:将64例紫杉醇或奥沙利铂引起周围神经病变的患者随机分为针刺组和西药组,每组32例。针刺组以疏经通络、益气活血化瘀、补益肝肾、养血柔筋为治则,穴取合谷、太冲、足三里、气海、曲池等;西药组采用肌肉注射腺苷钴胺。通过"化疗药物引起周围神经病变问卷"评价两组治疗前后神经毒性反应情况。结果:两组感觉神经障碍疗效比较,针刺组总有效率66.7%(20/30),西药组总有效率40.0%(12/30),两组比较差异有统计学意义(P<0.05)。结论:针刺优于腺苷钴胺治疗化疗药物引起的感觉神经障碍,尤以紫杉醇引起的中、重度感觉神经障碍疗效为佳。
Objective To seek the effective treatment for peripheral neuropathy induced by chemotherapeutic drugs. Methods Sixty-four cases of peripheral neuropathy induced by Paclitaxel or Oxaliplatin were randomly divided into an acupuncture group and a medication group, 32 cases in each group. The acupuncture group was treated with therapeutic principle of dredging meridians and collaterals, tonifying qi and eliminating blood stasis, supplementing liver and kidney, nourishing blood and tendon. Hegu （LI 4）, Taichong （LR 3）, Zusanli （ST 36）, Qihai （CV 6） and Quchi （LI 11） etc. were selected. The medication group was treated with intramuscular injection of Cobamamide. The neurotoxicity of two groups was compared with questionnaire of peripheral neuropathy induced by chemotherapeutic drugs before and after treatment. Results The total effective rate for sensory nerve disorder of acupuncture group was 66.7% （20/30）, which was superior to that of 40.0% （12/30） in medication group （P〈0.05）. Conclusion Acupuncture is more effective than Cobamamide for treatment of peripheral neuropathy induced by chemotherapeutic drugs, especially for moderate and severe sensory nerve disorder induced by paclitaxel.
出处
《中国针灸》
CAS
CSCD
北大核心
2010年第6期457-460,共4页
Chinese Acupuncture & Moxibustion
关键词
周围神经病变
奥沙利铂
腺苷钴胺
紫杉醇
针刺
随机对照试验
Peripheral Neuropathy
Oxaliplatin
Cobamamide
Paclitaxel
Acupuncture
Randomized Controlled Trials （RCT）
作者简介
许炜茹（1983-）．女，2008级北京中医药大学博士研究生。
通讯作者：花宝金（1964-）．男．主任医师。研究方向：中西医结合治疗肿瘤。E—mail：huabaojin@sohu．com
