摘要
[目的]探讨肾嗜酸细胞腺瘤的临床病理特征、免疫学表型及鉴别诊断要点。[方法]对2例肾嗜酸细胞腺瘤进行临床资料、大体、光镜观察,免疫组化染色,并文献复习。[结果]肾嗜细胞腺瘤2例,患者均为老年男性,肾脏单发实性占位病变,包膜不完整,界清,棕红色,质中等硬,其一可见中央星状瘢痕。光镜下,肿瘤组织由大小不一的巢状结构组成,伴有少量腺管,周围有纤细的血管纤维分隔。瘤细胞单一,圆形或多边形,有明显的嗜酸性胞浆,核圆,居中,未见核分裂象。2例均见局灶核异型,并见单细胞及小灶状坏死。免疫组化:两者均表达CK、E-cadherin、CD117,不表达CD10、Vimentin,其中1例CK7胞质阳性。[结论]肾嗜酸细胞腺瘤是比较少见的良性肿瘤,掌握其临床病理形态特征及免疫表型是正确诊断及鉴别诊断的关键。
[Objective] To further study the clinicopathologic features、immunohistochemical expression differential diagnosis of renal oncocytoma.[Methods] Two cases of renal oncocytoma were observed with clinical data analysis,gross and microscopic examinations,immunohistochemical stains,as well as review of the related literature.[Results] Both of the 2 patients were old man.The unilateral mass was found with clearly circumscribed,but lack of capsule,homogeneous consistency,dark-brown color.One of them showed a central scar.Microscopically,the tumors were composed of solid nests the classcical structure and small amount of tubules surrounded by vascular-fibrous stroma.The tumor cells were uniform,round or polygonal with moderate to abundant granular eosinophilic cytoplasm.The nucleus was round,centrally-placed,with the absence of mitotic activity.Both of them locally showed hyperchromatic and pleomorphic,as well as minimal necrosis.Immunohistochemical staining showed that CK、E-cadherin and CD117 were positive,but CD10 and Vimentin were negative in 2 cases.One of them showed positive staining of CK7.[Conclusion] Renal oncocytoma is not a common benign tumor.It is essential to master its clinicopathologic features and immunohistochemical expression for the differential diagnosis.
出处
《大连医科大学学报》
CAS
2010年第3期282-285,共4页
Journal of Dalian Medical University
关键词
肾肿瘤
肾嗜酸细胞腺瘤
免疫组化
kidney tumor
renal oncocytoma
immunohistochemistry
作者简介
张秋萍（1964-），女，辽宁朝阳人，副主任医师，硕士。E-mail：bsxcy@163．com
