摘要
目的:利用薄膜分散法制备紫杉醇微乳,并对其理化性质进行评价。方法:以外观、粒径、微乳的稳定性作为评价指标,筛选出最优处方。考察紫杉醇微乳的外观、pH值、乳滴形态、粒径、稳定性。用高效液相色谱法测定微乳中紫杉醇的载药量和包封率。结果:紫杉醇微乳为淡黄色澄明液体,pH值为4.83,性质稳定;透射电镜下观察微乳乳滴呈圆球形,分布均匀;粒径呈Gauss分布。紫杉醇微乳经氯化钠注射液和葡萄糖注射液稀释后,外观、pH值、载药量、粒径均无明显变化;载药量为3.032g·L-1,包封率为97.03%。结论:将薄膜分散法应用于紫杉醇微乳的制备,方法可行,制剂稳定,解决了紫杉醇水溶性差和过敏性强的问题。
OBJECTIVE： To prepare paclitaxel microemulsion using film dispersion method and to evaluate the physicochemical property of it.METHEDS： The prescription was optimized with appearance,particle size and stability of paclitaxel microemulsion as indexes.The pH,appearance,morphology,particle size,stability of paclitaxel microemulsion were detected.The drug-loading rate and encapsulation efficiency were determined by HPLC.RESULTS： The paclitaxel microemulsion was translucent diluted-yellow solution with pH of 4.83 and stable property.Paclitaxel microemulsion droplet in electron microscopy consists of small spherical drops and Gauss distribution.The appearance,pH,drug-loading rate and particle size of microemulsion were stable after diluting with sodium chloride injection and glucose injection.The encapsulated efficiency and drug-loading rate of paclitaxel microemulsion were 97.03% and 3.032 g·L-1.CONCLUSION： The film dispersion method could be applied for the preparation of paclitaxel microemulsion which stable.It could not only solve the problem of its poor solubility but also relief remarkable hypersensitivity.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第23期2139-2141,共3页
China Pharmacy
关键词
紫杉醇
薄膜分散法
微乳
制备
质量评价
Paclitaxel
Film dispersion method
Microemulsion
Preparation
Quality evaluation
作者简介
药师，硕士研究生。研究方向：药物新技术、临床药学。电话：0371—67690015。E—mail：zhou750423@126．com
