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血清HE4与CA125对卵巢恶性肿瘤的诊断价值 被引量:8

SERUM HE4 AND CA125 IN THE DIAGNOSIS OF OVARIAN CANCER
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摘要 目的探讨比较人血清附睾蛋白4(HE4)含量和CA125浓度在卵巢恶性肿瘤的鉴别诊断应用。方法用酶联免疫吸附试验检测三组妇女血清中HE4、CA125的水平。三组分别为体检健康妇女作为正常对照组(n=48)、按术后病理结果分为卵巢良性病变组(n=44)和恶性病变组(n=40)。结果①HE4、CA125在恶性病变组的水平与正常对照组和良性病变组比较均有显著的升高,差异有统计学意义(p<0.01);②血清HE4、CA125在卵巢癌的阳性检出率分别为72.5%和60%,与正常对照组和良性病变组比较差异有统计学意义(p<0.01);③HE4与CA125联测诊断卵巢癌的灵敏度为76.4%,阴性预测值82.3%,与HE4、CA125各单项检测值相比均升高。结论单项血清检测,HE4诊断卵巢癌灵敏度优于CA125;HE4与CA125联检,可进一步提高诊断卵巢癌灵敏度和阴性预测值。
作者 柯玲 刘发河
机构地区 茂名市人民医院
出处 《现代医院》 2010年第5期85-86,共2页 Modern Hospitals
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参考文献9

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