摘要
目的:探讨卵黄囊瘤(YST)的临床病理学特征、诊断和鉴别诊断、治疗和预后。方法:收集22例YST的临床病理资料,采用免疫组织化学、过碘酸雪夫(PAS)染色等方法来研究其病理特征。结果:YST临床主要表现为腹部肿块、睾丸肿大或CT发现纵隔巨大肿块。组织学改变镜下见肿瘤组织呈现网状结构、S-D小体结构和伊红染的透明小体形成。免疫组织化学及特殊染色:肿瘤细胞显示:22例AFP阳性(100%),22例CK(Pan)阳性(100%),15例PLAP阳性(68%),13例CEA阳性(59%),17例PAS(77%)阳性,HCG肿瘤细胞均阴性。结论:S-D小体结构和免疫组化AFP阳性表达在YST的诊断和鉴别诊断方面较为重要的意义。
Objective： To investigate the clinical and pathological characteristics, diagnosis, differential diagnosis, ther- apy and prognosis of yolk sac tumors （YST）. Methods ： The pathological data of 22 patients with YST were collected and their pathological features were studied by the methods of immunohistochemical technique, PAS staining and so on. Results： The main clinical manifestation of YST patients were the abdominal mass, swelling of the testis or the mediastinal huge mass detected by CT. Microscopically, there could be detected reticular tissues, the formation of schiller-duval （S-D） body and eosin-stain transparent body in the tumor tissues. Under immunohistochemistry and special staining, there could be found out that there were 22 cases of AFP and CK（Pan）-positive（100%）,15 cases of PLAP -positive （68 % ）, 13 cases of CEA- positive （59 % ）and 17 cases of PAS -positive （770%）in the tumor cells ,but no HCG -positive were detected. Conclusions ： The structure of S-D body and the immunohistochemical expression of the AFP-positive have played a very role in the diagnosis and differential diagnosis of the yolk sac tumour.
出处
《华夏医学》
CAS
2010年第1期60-62,共3页
Acta Medicinae Sinica
关键词
卵黄囊瘤
免疫组织化学
临床诊断
病理
yolk sac tumour
immunohistochemistry
clinical diagnosis
pathology
